Expected Results Data at ASCO Stellar results are expected now.
Market has been delaying recognizing this asset.
This would be the 2nd randomized trial + one bridging trial by Adlai, so so so 3rd trial results. This company would have pretty much derisked this asset to a minimum...
Management is building in high expectation already :
"Being selected for an oral presentation at ASCO is an immense honor that speaks to the importance of BRACELET-1's results to key opinion leaders and other critical stakeholders in breast cancer," said Dr. Matt Coffey, President and Chief Executive Officer of Oncolytics Biotech Inc
What we know so far from the December Aldai : Fifteen patients were treated in the trial as of the data cut-off date (September 26, 2022), with fourteen having had at least one post-baseline tumor assessment (i.e., evaluable for efficacy). All patients enrolled into the trial were previously treated with at least one endocrine therapy and no more than one line of chemotherapy for recurrent/metastatic disease. Data and conclusions presented in the poster are summarized below.
- Disease control, partial response (PR) or stable disease (SD), was achieved in thirteen of fourteen evaluable patients (93%), with twelve (86%) showing tumor shrinkage from baseline.
- Seven of fourteen evaluable patients achieved a PR (50%). Three of these patients achieved a confirmed PR (20%), while two patients are awaiting potential confirmatory scans.
- One patient achieving a PR at week 8 has maintained the PR through week 48 and remains on study.
- Evolving median progression-free survival (PFS) for trial participants as of the data cut-off date was 9.1 months (95% confidence interval: 3.8 - NA).
- The studied combination has been well tolerated, with no dose-limiting toxicities or serious adverse events (SAEs) reported to date.