RE:RE:RE:ASCO relevance". If Pela converts cold cancers to hot and improves survival after immunotherapy, the story is done and the share price will take care of itself. This is a multi-billion $$ indication."
Bravo Carey. We are in full agreement on this point.
Thus far the clinical results have demonstated that pelareorep to turn cold tumors "hot", and I have elaborated on how pelareorep is able to modulate INF (gamma) and downregulate HIF (alpha) to both stimulate the innate immune system and convert an otherwise immunosuppresiive tumor microenvironment (TME) for the addition of PD-(L)1 immune checkpoint inhibitors thus enabling the conversion of a cold tumor into a "hot" tumor.
Just go through all of my posts to see the immunological pathways involved in this conversion.