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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to phase 3 licensure-enabling studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > Looks Good-ONCY SITC 2023 Poster in metastatic breast cancer
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Post by Noteableon Nov 04, 2023 2:43pm
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Post# 35717590

Looks Good-ONCY SITC 2023 Poster in metastatic breast cancer

Looks Good-ONCY SITC 2023 Poster in metastatic breast cancerNovember 04, 2023 - Analysis of the HR+/HER2- breast cancer tumor microenvironment (TME) following immune priming with pelareorep and atezolizumab using imaging mass cytometry - Results from the AWARE-1 trial

Pelareorep primes the TME in advance of atezolizumab administration resulting in a decline of PDL1 tumor cells after addition of Tecentriq.

The increase of PDL1 expression on day 3 and the following decrease on day 21 as seen by IHC can likely be attributed to the reduction of PDL1 positive tumor cells as a result of treatment.

https://oncolyticsbiotech.com/wp-content/uploads/2023/11/SITC_Poster_FINAL.pdf

https://www.biospace.com/article/releases/oncolytics-biotech-and-solti-present-further-positive-pelareorep-translational-data-at-sitc/
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