Lyophilization: The stability of RNAs and proteins, which were lyophilized and stored at room temperature (23°C) for 14 days examined by RT-PCR, SDS-PAGE and western blot demonstrated that lyophilization did not alter total protein activities of various tissues, including enzyme activities, immunoreactivities and phosphorylation, and did not affect several RNAs in lyophilized tissues. Taken together, lyophilization represents a valuable approach for preservation and long-distance shipment of biological samples, particularly for the international exchange of biological samples without altering their bioactivities.
1. What is typical for distribution and storage temperature?
For the most part, the desired average refrigerator vaccine storage temperature of 5°C is typical for distribution and storage temperature for a vaccine.
2. Do Lyophilized vaccines require the same kind of temperature control that liquid vaccines do?
Lyophilized vaccine powder is simply a freeze-dried version of their liquid form. The process of freeze-drying the vaccine turns it into a dry disc or powder. When vaccines are in their lyophilized form, they should be stored in refrigerated conditions.
https://pubmed.ncbi.nlm.nih.gov/22215254/