Oncolytics Biotech Inc T.ONC

DCs and NK cells as the enhancer of OVs

[Noteable]

January 10, 2023 - "... efforts are being undertaken to prevent the immunosuppression that is linked with tumors. Anti-cancer treatment based on oncolytic viruses is one of the most fascinating therapeutic techniques for addressing such challenges (oncotherapy). OVs selectively target and destroy cancer cells through direct oncolysis and antitumor immunity (115).

Immunosuppression inside the tumor microenvironment (TME) provides an environment that is susceptible to infection and is permissive to viral multiplication, in the end, this leads to death of cancer cells. Upon OV-induced immunogenic cancer cell death and the subsequent "danger" signals, there is an increase in APC and lymphocyte infiltration in the TME.

This rise in APC and lymphocyte infiltration leads to the stimulation of nonspecific and specific anti-tumor response, reducing the risk of cancer recurrence over the long term (116). OVs are also responsible for the activation of additional immune responses, which serve to counterbalance the decrease in the presentation of tumor antigens and to boost the interaction of APCs with T cells that are specific to the tumor ..."

https://www.frontiersin.org/articles/10.3389/fimmu.2022.950079/full

[Noteable]

"... OVs have the advantage of “warming up” immunologically cold tumors to the level of an immunologically activated malignancy ..." "... Additionally, it has been discovered that by encouraging dendritic cell maturation and the polarization of macrophages to the M1 phenotype, the OV@NK system can alleviate immunosuppression in the TME. Both in vitro and in vivo

[TitanBrawler]

Great news .. maybe will get a 60 billion dollar buyout soon. Lol

[Buckhenry]

that's toooo low man... with the posts of unnoteable and his baby pumpers following i expect no less than 100B.    they got the inside track and have a direct line to Matt. 

[Noteable]

Dendretic cells (DC) and T-cells (NK cells) are an effective way of delivering ONCY's pelareorep (reovirus) to the patient through intravenous administration.

[TMAZZ21]

Noteable, curious to know how many shares do you own? You must be heavily invested, there's no way your spending this much time posting and not be heavily invested! Let's hope your right and this dream becomes a reality! :)