Post by
canadafan on Jun 11, 2024 4:45pm
Multiple thoughts.
thanks again noteable for exaplsing the variou approval pathways.
Ultimately, the approval for Pelareorep be marketed is the only goal.
onc mangemet did not on their own randomly decide to bring about Bracelrt, Aware-1, or Gobblet.
All were initiated at request if FDA & the various colaborators. Pfizer, Roche, Incyte.
The PanCan organization etc etc.
There are many outside eyes watching & validating the various trials & outcomes.
One reason Noteable needs to repeat things as a few side show band of bashers, either collectively have an I.Q. That of a baked potato, or just continue to throw out random distractions.
Granted there are legitimate concerns. Saying phase 3 could have been started 3 years ago, ..or when ever?
it was at the time when they were granted FDA fast track for MBc, that things were looking full speed ahead.
it was clearly discussed at the time to de- risk the trials , the FDA advised a window of opportunity study to identify pre- full- on treatment, a biomarker.
Aware-1, & subsequent trials have indntified two.
That being after 2 weeks , a blood draw will indicate if the patient can respond or not to Pela.
That very science, is the partial request of the FDA type C meeting.
in plain language, they can reduce patient numbers, (/saves $$), and reduce overall length if trail ( saves $$) and ..the derisking part.
Simple, yet very significant.
pre- screening non- responders, can statistically increase the efficacy Benefits.
hence..de- risking the phase 3 trial.
THAT, came from advice from FDA.
build the best trial possible, with the best pre- trial screening. Thereby reducing the likelihood of trial failure.
regretably has taken more time.
Now?
Axe soon as FDA responds, the MBc phase 3 trial will be in concept ready to roll.
next step?
who will be the partner to move that forward.
if I was one of those with a few billion $ at risk. I'd wait until the FDA responded.
Having as much info as reasonably possible.
That is good business & good science.
The Gobblet , pancreatic , anal etc was an added bonus in the wait.
I respect , Noteable for his tenacity.
memem keeps asking about a date. Like the old records that kept skipping.
The date will be when we see a N.R. With details.
Not far away.
Comment by
Azzak34 on Jun 12, 2024 2:25pm
The reason I asked is because you continually tell us all what you've done after the fact!! Forecast entry and exit for 3 stocks you've recently bought in to so we can assess your ability to "pick em"! Tesla is 1, give us another 2.
Comment by
Azzak34 on Jun 12, 2024 2:27pm
How's BCT working out Nemo?
Comment by
ENEMENEMYNEMO on Jun 12, 2024 2:36pm
Mehhhh. I was expecting more
Comment by
Azzak34 on Jun 12, 2024 2:43pm
Bit of a pattern emerging eh? Only down 35% since you pumped it so you're definitely improving.
Comment by
ENEMENEMYNEMO on Jun 12, 2024 2:58pm
60% since I bought actually. But that's biotech! No worries I can afford it.
Comment by
Azzak34 on Jun 12, 2024 3:43pm
I admire your honesty but when you pick as many losers as you do maybe hold off on the advice!? Just a thought.
Comment by
ENEMENEMYNEMO on Jun 12, 2024 6:09pm
Exactly....and look here I am!!!
Comment by
Buckhenry on Jun 12, 2024 8:27pm
Canuckfan must live in his mother's basement with nothing else in life to do but post on here and eat cheetos.
Comment by
Peladawn on Jun 13, 2024 10:56am
You mean exactly like what you're doing, Bucky?
Comment by
Buckhenry on Jun 13, 2024 5:09pm
Nothing personal but none of us care about each other's personal life issues. I pity the the pumpers for all their worthless rhetoric and regurgitation. Grow a pair canuckcluck.
Comment by
Buckhenry on Jun 13, 2024 5:20pm
You folks need to STOP emotionalizing, dramatizing, and sensationalizing everything here. Let it it role off and have fun or go somewhere else... either way I don't give a rats booty.
Comment by
Azzak34 on Jun 13, 2024 5:24pm
I agree Buckster people get too worked up about all sorts of things, crazy really!! Can you tell me who John Doe 174 is?
Comment by
Buckhenry on Jun 13, 2024 5:29pm
John doe 174 sits behind John doe 173 and next to Jane doe 174..
Comment by
Azzak34 on Jun 13, 2024 5:34pm
Any thoughts on the real identity?
Comment by
Buckhenry on Jun 13, 2024 6:47pm
After exhaustive research I have the answer to who John doe 174 is... he is on the board at oncy in charge of screwing the shareholders over... and he is very good at his job.
Comment by
Peladawn on Jun 13, 2024 6:55pm
Well.. I had no idea!...I'm definitely going to sell all my shares tomorrow!.....thanx, Bucky.....so, which of of your loser stocks should I buy into?
Comment by
Noteable on Jun 13, 2024 8:06pm
A federal judge unsealed the names of nearly 200 "Does" affiliated with Jeffrey Epstein. A Business Insider analysis of court records found Donald Trump is John Doe 174.
Comment by
Azzak34 on Jun 14, 2024 1:59am
Imagine that. Single standard for all!!!
Comment by
Angler101 on Jun 14, 2024 8:31am
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Comment by
Noteable on Jun 14, 2024 9:12am
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Comment by
Azzak34 on Jun 14, 2024 9:14am
I would hope anyone who was associated with that gentlemen should be investigated in order to clear their name of wrong doing or implicated in his crimes. That's for both sides of the aisle, no matter who!!!!
Comment by
Noteable on Jun 14, 2024 9:19am
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Comment by
Noteable on Jun 14, 2024 9:22am
The more rope you give Trump's supporters, the more they hang themselves
Comment by
CMHarring218431 on Jun 14, 2024 9:30am
Opening up a can of worms here. How about Billy Cllinton, actually photographed with him. As Angler said.....should we list the others? I was on St. John this winter and off my deck you could see Epstein's compound. Such a coincidence Oh by the way, Someone should tell Biden that as a politician you are allowed to kiss babies. He seems to be a little too fond of little girls
Comment by
Azzak34 on Jun 14, 2024 9:34am
Single.standard.for.all!!!
Comment by
Peladawn on Jun 14, 2024 8:41am
Hey Azzak....thought you and the other disingenuites said something about this forum was only for discussing Oncy....I guess only when it suits your purposes, right?
Comment by
Azzak34 on Jun 14, 2024 8:47am
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Comment by
Peladawn on Jun 14, 2024 9:02am
Well, you oughta know about hypocracy.
Comment by
Peladawn on Jun 14, 2024 9:10am
There ya go...you're just as good at spelling it as living by it.
Comment by
Peladawn on Jun 14, 2024 9:16am
Hey, Certifiable.....those "newly uncovered docs." you were so delighted to post about, were "newly uncovered" more than 5 months ago....lol....wow.....must be a real blockbuster!....
Comment by
Peladawn on Jun 14, 2024 9:25am
If there was even one tiny shred of evidence of a crime in those documents, Trump would have had at least 34 more charges against him, about 5 months ago.....but keep digging....maybe you can find something, somewhere, somehow, even if you have to make it up, like Bragg, to keep Trump off the ballot....you know....in the name of "democracy".
Comment by
Noteable on Jun 14, 2024 9:29am
There is more than just a "shred" of evidence, Trump has a 78 year history of aberrant behavior and defending "democracy" is not on that list.
Comment by
Noteable on Jun 14, 2024 9:56am
"Billy Beer" and Trump's 'acquaintance' in Epstein's 'human traffickng' of young women are oxymoronic since Trump doesn't drink beer.
Comment by
Peladawn on Jun 14, 2024 10:00am
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Comment by
Noteable on Jun 14, 2024 10:28am
Another example of pimping the contestants: "Later in the same tape, Trump can be heard talking up his son, Eric – who also served as the contest’s judge – to the assembled beauty queens: “I have a son, he’s very handsome; he’s 6-foot-6, and he was number one in his class in school.”
Comment by
Peladawn on Jun 14, 2024 10:36am
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Comment by
Azzak34 on Jun 14, 2024 10:43am
You're getting too excited. Calm down and apply your morality. If the other guy has committed crimes he should be held accountable too. Why are you not understanding that??
Comment by
Azzak34 on Jun 14, 2024 11:05am
So if he broke the law he should be held accountable!!! I don't know how to state it differently. Are you saying your guy didn't break laws? Or you're saying he did but so did the other guy and both should be convicted? Or both let off? Ideology shouldn't operate without morality. That's extremism.
Comment by
Noteable on Jun 14, 2024 11:21am
Peladawn are you just plain stupid?
Comment by
Noteable on Jun 14, 2024 12:14pm
"y'all enjoy your non pasteurized milk" - perfect categorization of those wearing tin foiled hats tuned into fox.
Comment by
Noteable on Jun 14, 2024 12:34pm
Russian inflation on the rise - UP +8.5% in May 2024 versus +7.8% in April 2024 and 2.5% in May 2023
Comment by
Noteable on Jun 14, 2024 11:30am
Biden is not being indited under the Espionage Act. https://abcnews.go.com/Politics/trump-faces-31-charges-espionage-act-law-regulating/story?id=100129183
Comment by
Noteable on Jun 14, 2024 11:34am
Trump ig being indited under the Espionage Act. “In this case, former President Trump hasn’t been charged with spying for a foreign government, or espionage as we normally think about it, but he has been charged with willfully withholding national defense information – which is the way that a case like this is normally charged,”
Comment by
Noteable on Jun 14, 2024 12:12pm
venture009 : your lack of knowledge gives away your age and lack of other understrandings For example: INDICT - to charge with a fault or offense https://www.merriam-webster.com/dictionary/indict
Comment by
Peladawn on Jun 14, 2024 4:26pm
Lol.....obsessed much?....wow!....you must have a hate trump room in your house with the walls covered from floor to ceiling with hate trump articles and a dart board with trump's picture tacked up in the centre of it....lol....I'll even bet that you're the freak that wrote the book called "80,000 lies told by Donald Trump"....looney tunes!
Comment by
Noteable on Jun 14, 2024 7:12pm
Biden came after Trump. It's like the landlord having to clean up after a bad tenant.
Comment by
Noteable on Jun 15, 2024 11:53am
Yes .. really. And I have explained the mess that the Yrump administration made in a rules based society. Immigration is a red herring to cover the 'human trafficking'' happening in the pimps world of beauty contests and high top sneakers.
Comment by
Peladawn on Jun 15, 2024 12:20pm
Oh, I see.....10 million unvetted people allowed into the country by the Democrats, is a red herring to cover up what Donald Trump is doing.....man, you TRULY ARE DELUSIONAL!!!
Comment by
Peladawn on Jun 15, 2024 1:46pm
Just like any good demautocrat....if you have no reply to the facts, shut down the conversation and stick your head in the sand and hope it all goes away.....no wonder this country is so hopelessly divided
Comment by
Lesalpes29 on Jun 15, 2024 8:56pm
Ignore Peladumdum! Done that since a long time. Orange p.. lovers... I know I know... you know everything and you believe. 'Ce que je sais ... c'est qu'on ne sait jamais vraiment'... Hockey game to watch. GL to all oncy's lovers!
Comment by
Noteable on Jun 17, 2024 9:43am
https://www.thedailybeast.com/trumps-spiritual-adviser-robert-morris-half-confesses-to-molesting-12-year-old-girl
Comment by
Noteable on Jun 15, 2024 1:49pm
Shouold read: " ...Baturina was the richest woman in Russia due to her real estate construction business in Russia, a business that she expanded to Crimea. ..."
Comment by
Noteable on Jun 14, 2024 11:46am
Peladawn you are too stupid to be real.
Comment by
Azzak34 on Jun 14, 2024 11:52am
Pela does have a point with that, one, if he knowingly lied about the laptop and subsequent accusations he should absolutely be held accountable. That was vital information and if it was indeed suppressed and covered up there has to be consequences.
Comment by
venture009 on Jun 14, 2024 11:08am
If some type of cooperation with our "enemy "is what it takes to have world peace may be more of it should be done. Isolation only causes more uncertainty and conflict. The western press does everything to promote conflict especially with Russia to what end ? A WW III benefits no one.
Comment by
Noteable on Jun 14, 2024 11:20am
'.. cooperation with our "enemy " ' The same "enemy' who happens to be at war with our "friends" belonging to both the EU and NATO? Does your "twisted" view on reality somehow have a Russian/Putin /Trump bent to it?
Comment by
Peladawn on Jun 14, 2024 10:13am
STOP THE PRESSES.....Notacertifiable has discovered a billionaire that likes to have sex with women....most certainly .the first time in history that has ever happened!....get help, Note....and don't be afraid to pay a little more to get the very best.....I wish you well.
Comment by
Azzak34 on Jun 14, 2024 9:30am
But Pela can't we agree that everyone should be investigated for all crimes they are suspected of? As long as there is supporting evidence of course!
Comment by
Peladawn on Jun 14, 2024 9:44am
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Comment by
Azzak34 on Jun 14, 2024 10:08am
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Comment by
Peladawn on Jun 14, 2024 10:17am
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Comment by
Peladawn on Jun 14, 2024 10:33am
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Comment by
Peladawn on Jun 14, 2024 10:41am
Btw Azzak...."hypocrite"....lol...you're going to need a shoehorn for that one
Comment by
Noteable on Jun 15, 2024 2:10pm
Ukraine's landscape of organized crime and the lack of "rule of law" - which Trump would like to probagate. https://www.ojp.gov/pdffiles1/nij/grants/198321.pdf
Comment by
Noteable on Jun 15, 2024 2:44pm
Should read: " Ukraine's landscape of organized crime and the lack of "rule of law" - which Trump would like to propagate ..."
Comment by
Peladawn on Jun 15, 2024 2:55pm
No Notable.....should read...."Russian oligarch donates $100 million to Hunter Biden's "real estate firm".....https://nypost.com/2022/10/17/hunter-bidens-real-estate-firm-received-over-100m-from-russian-oligarch/
Comment by
Peladawn on Jun 15, 2024 3:02pm
And the reason Trump sided with Putin against the FBI, is because he trying to fight against the fake Russian Dossier threat the Hillary Clinton campaign dreamed up and paid for and along with the corrupt, weaponized FBI, lied to the American people about for years, and are still lying about it.
Comment by
Peladawn on Jun 15, 2024 3:38pm
The Bidens and their associates have received over $20 MILLION from several foreign entities, all prove by subpoenaed bank records.... Romania $3m China. $8m Ukraine. $$6.5m and, oh yeah....$3.5 million from the Russian Lady Oligarch your fake propaganda articles are trying to link Trump with. lol. https://oversight.house.gov/the-bidens-influence-peddling-timeline/
Comment by
Peladawn on Jun 15, 2024 3:41pm
It's obvious now why the Biden's met with her and why Joe Biden sat back and did nothing while Russia rained missiles on Ukraine.
Comment by
Noteable on Jun 15, 2024 4:58pm
fake news in the "oversight.house.gov" page that Peladawn posted in trying to pass it off as something official - whicxh it isn't. Its unabashed political propaganda. https://oversight.house.gov/the-bidens-influence-peddling-timeline/
Comment by
Noteable on Jun 15, 2024 5:02pm
Ukraine's landscape of organized crime and the lack of "the rule of law" - which Trump and his "Cult following" would like to propagate. https://www.ojp.gov/pdffiles1/nij/grants/198321.pdf
Comment by
Peladawn on Jun 15, 2024 5:11pm
lol....so according to Notable, some article from some left wing reporter is official news, but a report form the US House of Representatives Oversite Comittee is "unabashed political propaganda"....lol...incredible!
Comment by
Noteable on Jun 15, 2024 5:28pm
Ukraine's landscape of organized crime and the lack of "the rule of law" - which Trump and his "Cult following" would like to propagate can be no clearer exemplified than in the 'spin' of Peladawn's posts.
Comment by
Noteable on Jun 15, 2024 5:34pm
Peladawn - drink a glass of some unpasteurized milk while you are at it.
Comment by
Noteable on Jun 18, 2024 11:10am
https://www.timesofisrael.com/kgb-groomed-trump-as-an-asset-for-40-years-former-spy-says/
Comment by
Noteable on Jun 18, 2024 11:12am
https://www.theguardian.com/us-news/2023/oct/17/russian-sources-disappeared-after-trump-declassified-ex-spys-evidence-uk-court-told
Comment by
Peladawn on Jun 18, 2024 11:50am
LOL......Notable is like a child's toy....you just gotta wind her/him/they up and watch it spin itself into a self-induced Trump-hatred euphoria.....
Comment by
Peladawn on Jun 18, 2024 12:04pm
Whitehouse now claiming videos of Biden's recent dementia-induced freezes are nothing more than deepfake manipulations.....lol....I can't wait for the comedy show of the decade, the presidential debate, in just a few days....get out the popcorn!
Comment by
Peladawn on Jun 18, 2024 12:08pm
LOL!.....Biden's own Fed Chairman just came out and stated that the jobs report, quote, "may be a little overstated".......lol!.....priceless!....
Comment by
Noteable on Jun 18, 2024 12:19pm
Steele dossier on "troubling information indicating connections between Trump and the Russian government" https://en.wikipedia.org/wiki/Steele_dossier
Comment by
Noteable on Jun 18, 2024 12:20pm
https://slate.com/news-and-politics/2018/02/the-nyts-crazy-russian-spy-story-explained-by-its-author.html
Comment by
Noteable on Jun 18, 2024 12:22pm
Brad Thompson invoved Russians to run the H&N study.
Comment by
Noteable on Jun 18, 2024 12:24pm
https://www.politico.com/magazine/story/2017/03/connections-trump-putin-russia-ties-chart-flynn-page-manafort-sessions-214868/
Comment by
Noteable on Jun 18, 2024 12:44pm
In May 2023 the Washington Post reported that " A Russian millionaire with ties to the Kremlin was convicted in February of participating in an insider-trading scheme that involved the hacking of securities filing agencies to get advance knowledge of earnings reports. The hacking was allegedly conducted by a Russian military officer, Ivan Yermakov. "
Comment by
Journeytc on Jun 18, 2024 12:54pm
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Comment by
Peladawn on Jun 18, 2024 1:09pm
The infamous Steele Dossier was bought and paid for by the Hillary Clinton campaign, and was proven beyond any doubt, years ago, to be absolutely fake, and Hillary Clinton was fined $8000 for it......and delusional Trump Haters like Notable are still trying to convince the world that it was real.....very sad!....
Comment by
Peladawn on Jun 18, 2024 1:23pm
Trump gets "convicted" on 34 counts for supposed election interference ,and Hillary gets a laughable $8000 fine for paying Steele with campaign funds to manufacture a fake dossier to affect the 2016 election.....VERY SAD!......
Comment by
Noteable on Jun 18, 2024 1:31pm
Peladawn is a Trump Cultist trying to spin the truth into something else.
Comment by
Peladawn on Jun 18, 2024 1:39pm
lol.....hey Notable.....thanks for proving my point....this is from the 5th paragraph of the article in the first link you posted on the fake Steele Dossier.... The so-called Steele dossier assembled in 2016 created a political storm just before Trump’s inauguration with rumors and uncorroborated allegations that have since been largely discredited.
Comment by
Noteable on Jun 18, 2024 1:49pm
Rumors like you Peladawn have been trying to spread are the type of uncorroborated allegations that have been discredited, while the truth about Trump's Russian relationships and real estate deals with Russian billionaires and Trumps' Russian funded superfunds can never be contested.
Comment by
Peladawn on Jun 18, 2024 1:57pm
No, of course they can't be disputed, Notable, because your idea of truth is believing only what you want to believe and totally ignoring everything else.....have a nice day freak....I prefer to converse with someone with common sense....ta ta!....
Comment by
Noteable on Jun 18, 2024 2:05pm
.... common sense ... isn't that the rallying call and populist meme of the ultra right unpasteurized milk drinkers?
Comment by
Noteable on Jun 18, 2024 3:48pm
https://en.wikipedia.org/wiki/Steele_dossier
Comment by
13X2413 on Jun 18, 2024 6:22pm
Noteable, it was bad enough when you posted relentlessly about information unrelated to ONC. Now you've switched to political nonsense!? C'mon man!!!!
Comment by
Noteable on Jun 18, 2024 6:28pm
Just informing the likes of Peladawn of the facts in contrast to their fiction.
Comment by
Noteable on Jun 18, 2024 6:29pm
In contrast to their unpasteurized milk nonsense.
Comment by
13X2413 on Jun 18, 2024 7:07pm
I like you a lot better when you stick to ONC.:)
Comment by
Noteable on Jun 21, 2024 4:01pm
https://www.forbes.com/sites/siladityaray/2024/06/21/50-million-contribution-from-billionaire-timothy-mellon-leads-huge-fundraising-month-for-trump/ https://www.bbc.com/news/articles/c9eed9g3vlyo
Comment by
Noteable on Jun 21, 2024 4:07pm
Looks more than "elitist" to me ! https://www.nbcnews.com/politics/2024-election/timothy-mellon-leads-huge-month-trump-megadonors-pouring-cash-election-rcna158204
Comment by
Peladawn on Jun 21, 2024 6:44pm
Better still, why don't you mention the 13 yr old girl just murdered by 2 illegal migrants because of Biden's illegal border policy that he's been lying to us about for 3 1/2 years and blaming it all on Republicans.
Comment by
Noteable on Jun 21, 2024 7:05pm
Well Peladawn you've proved my point about those "elitists" you've been railing against. Now grow a pair.
Comment by
Peladawn on Jun 21, 2024 7:28pm
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Comment by
Noteable on Jun 21, 2024 7:52pm
So tell me Peladawn, how does that deal with the "billionaore elists" that you've cited?
Comment by
Noteable on Jun 22, 2024 3:35pm
https://www.youtube.com/watch?v=zA_i16jhiiU&ab_channel=FiringLinewithMargaretHoover%7CPBS
Comment by
Peladawn on Jun 18, 2024 12:29pm
Biden, yet again by-passing Congress, has just announced "Mass amnesty for migrant spouses".... what a surprise....lol....everyone has known all all along that the reason for the wide open border that has allowed over 10 million illegal migrants into the country, is to permanently change the voting block in favour of the Demautocrats....election manipulation at it's finest....again!
Comment by
itntdf on Jun 18, 2024 12:59pm
yean, kinda like when malaria married cheeto christ in 2005 but didn't become a citizen until a year and a half later. she also had an anchor baby (barron) and sponsored her parents to come here. guess we should round them up and deport them. but on second thought, maybe not. they are white, not brown.
Comment by
Peladawn on Jun 18, 2024 1:16pm
itntdf......what the frack are you babbling about?
Comment by
Buckhenry on Jun 18, 2024 12:21pm
Guess it's mighty slow here to be talking politics... I found something the pumpers know even less about....