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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. It blocks viral entry into host cells while preserving normal immunologic function. The Company is also investigating an intramuscular method of administration of Trogarzo. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy.


TSX:TH - Post by User

Post by qwerty22on Jul 24, 2020 12:19pm
119 Views
Post# 31314726

Recent example of an ADC in cancer

Recent example of an ADC in cancerGSK got an antibody drug conjugate approved recently.

https://www.ema.europa.eu/en/news/first-antibody-drug-conjugate-multiple-myeloma-patients-limited-treatment-options

This drug is similar to the concept of Theratech's drugs, replacing the SORT peptide with an antibody though (and to a different cancer antigen).

I thought the development timeline was interesting to look at.

The Ph1 started in 2014. They were reporting efficacy data from that trial by 2016
The Ph2 started in 2018 and we already now have approval.

I think there was speculation that you could get the first patients in Theratech's trial in 15 months. That might be true but a clear(ish) picture on efficacy may take a little longer but as you can see once you have that in the bag things can advance pretty swiftly.
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