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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. It blocks viral entry into host cells while preserving normal immunologic function. The Company is also investigating an intramuscular method of administration of Trogarzo. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy.


TSX:TH - Post by User

Comment by Wino115on Oct 04, 2021 8:27pm
154 Views
Post# 33965166

RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:My opinion

RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:My opinionThe extension of PFS to 27 months is impressive.  This is 2L and HER2+ breast cancer is about 20% of cases.
Great news for patients.  It seems it's becoming the standard for HER2+. Given the targeting issues, I guess Enhertu will only work for the HER2+ subset so may not be useful for THTX to attach for all solid tumors in 4L setting.  But those numbers would be something to shoot for! 

qwerty22 wrote:

One MD gushing over Enhurtu.

https://www.medpagetoday.com/meetingcoverage/esmovideopearlsmetbreastca/94758

 

qwerty22 wrote: Enhurtu. Must be putting pressure on all those breast cancer only drug developers. Hopefully we get breast+another.

"The FDA has grant­ed break­through des­ig­na­tion to As­traZeneca's and Dai­ichi Sanky­o's HER2 ADC En­her­tu, the com­pa­nies joint­ly an­nounced to­day.

 

The BTD is for the treat­ment of adult pa­tients with un­re­sectable or metasta­t­ic HER2 pos­i­tive breast can­cer who have re­ceived one or more pri­or an­ti-HER2-based reg­i­mens.

Break­through ther­a­py des­ig­na­tion was based on da­ta from the DES­TINY-Breast03 piv­otal tri­al at #ES­MO21 just last month, which showed a 72% re­duc­tion com­pared to Roche’s ADC Kad­cy­la in the risk of dis­ease pro­gres­sion or death in pa­tients with HER2 pos­i­tive un­re­sectable and/or metasta­t­ic breast can­cer pre­vi­ous­ly treat­ed with trastuzum­ab and a tax­ane.

“This is an im­por­tant step in bring­ing En­her­tu as a po­ten­tial new op­tion in ear­li­er lines of treat­ment for HER2 pos­i­tive metasta­t­ic breast can­cer, giv­en the ur­gent need to im­prove out­comes,” said As­traZeneca EVP of on­col­o­gy R&D Su­san Gal­braith in a state­ment.

Pre­vi­ous BTDs for the drug were in late-line HER2 pos­i­tive metasta­t­ic breast can­cer in 2017 and HER2 mu­tant metasta­t­ic non-small cell lung can­cer (NSCLC) and HER2 pos­i­tive metasta­t­ic gas­tric can­cer in 2020."





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