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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. It blocks viral entry into host cells while preserving normal immunologic function. The Company is also investigating an intramuscular method of administration of Trogarzo. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy.


TSX:TH - Post by User

Comment by qwerty22on Oct 30, 2022 3:31pm
54 Views
Post# 35058672

RE:RE:RE:Principal investigator for TH1902

RE:RE:RE:Principal investigator for TH1902

Shah was a good choice for that PR. His comment added something (a little to a little).


Wino115 wrote: I can understand why the PR around the dosage/safety 1a only had a quote from the Dr where the various responses were, but I would hope that going forward THTX is able to solicit useful comments or views from their lead investigator along the lines of the quote posted. Hopefully from Rothenburg too.  Leading industry voices would add credibility, especially for an unknown company and unknown target. 
 

qwerty22 wrote:

Just for comparison
May 2021 they announce first patient dosed (THTX MAR 2021)
Oct 2022 they are announcing 18 evaluable patients (THTX JULY 2022)

Pretty much similar timelines.

Big difference is they got one complete responder in their first 3 patients dosed so they were able to put out an early sign of efficacy PR in Oct 2021. Lucky dogs.

These guys are a private company so they don't have the same obligations to go public with data but they aren't revealing much about anything else. Vague statement on safety/tolerability. Nothing on other Ph1 stuff like pK, stability etc.

 

scarlet1967 wrote:

 

She is the principal investigator at MD Anderson also in charge of TH1902 trial.

This was her comments about another PDC at the Clininc:

 

“In this phase I study, CBX-12 demonstrated safety and tolerability, without significant gastrointestinal toxicity. We also saw signal of antitumor activity in multiple tumor types, said principal investigator, Funda Meric-Bernstam, M.D., Chair of the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center.”

 

https://www.globenewswire.com/news-release/2022/10/28/2543911/0/en/Cybrexa-Therapeutics-Presents-Findings-from-First-in-Human-Study-of-CBX-12-as-a-Plenary-Oral-Presentation-at-34th-EORTC-NCI-AACR-Symposium.html

 

Looking at her profile she seems to be the right choice for TH1902 so hopefully we get a similar PR with encouraging comments from her about TH1902.

 

 

 

 

 

“Funda Meric-Bernstam is the Chair of the Department of Investigational Cancer Therapeutics -- the Phase I Program, and the Medical Director of the Institute for Personalized Cancer Therapy at MD Anderson Cancer Center. She has a basic and translational research program that is focused on molecular therapeutics, to delineate the mechanism of action of each agent targeting this pathway and the molecular alterations useful to prospectively identify patients who will benefit most from each agent, and optimal combination therapies with targeted therapies and novel immune-modulators. She is an active clinical trialist focused on Phase I trials, and rationale combinations, biomarker-driven therapy and immune-oncology.”

 

Funda Meric-Bernstam | MD Anderson Cancer Center


 




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