Theratechnologies Inc T.TH

RP2D

[SPCEO1]

The RP2D, or recommended phase 2 dosage, is one step below the MTD. So, the 300mg dosage level, or about 1.5x the normal docetaxel dose seems to be the early leader for the RP2D. The higher the dosage level TH can use in phase 1b and phase 2, the better the chances of success. In the pre-clinical charts, the best results were gleaned when the dosage of TH-1902 was a little more than 2x that of docetaxel. So, ideally, the 420mg level would be the RP2D.

Does anyone have any idea why TH does not want to share more specific information on the number of patients dosed at 420mg, whether this is the second time at this level and exactly how long it now looks like it will take them to complete the trial. JFM was ironically suggesting the summer for the trial's end earlier but that could turn out to be correct. 

I really do not understand why TH management has allowed us to be so confused about these basic matters. They already have a credibility problem and these delays are not helping fix that.

[Wino115]

Notes from the page before the dose chart. They still could be escalating. We know in Nov they hit that one SAE, then said they needed to get 3 to that level. Given the length of time, it must have been they needed to actually enroll 3 new ones and didn't have any previous patients to just ramp it up to that level. THen you have to do a full cycle of 3 weeks.  Since they haven't

[palinc2000]

Maybe its time to quit making assumptions about timing  and results.....Wild speculation at best....If you want answers maybe you should change your mind about meeting with management

[Bucknelly21]

Pretty disappointed....

[stockman75]

nothing new. Not least bit surprised.   

[palinc2000]

I think the more people fantasize about timing and results in a Phase 1 clinicak trial the more they are setting themselves up for major disappointment.Management does not interact in the human body ..... the drug does the work and drugs that make it all the way to Fda approval are not controlled by management once inside the body....One poster was already thinking that the dosage was so high as

[mikeq113]

Whoever updated that presentation must get paid by the hour. 

[Momo25]

@palinc, don't try to justify their inconsistency. Business is business and business it has rules and principles. They commit to deliver something by the end of the 2021. They missed the milestone. Fine ! They need to provide information to the shareholders so we can understand what is going on and take action accordingly. We are human being too. More than that, we've put our money in this

[LouisW]

To me, the progress is accetable despite it is slower than what i was expecting. If they encounter DLT in multiple patients, they will be forced to step down to 1.5x dosage. At least, they are evaluating 2X dosage and not experiencing any DLT yet. I am totally fine if MTD is 2x dosage. Yesterday, XBI was down 1.6%, however, THTX was up 3% with . Coincidentally, TH has clarified the clinical