Post by
scarlet1967 on Jun 13, 2023 8:03pm
Rebranding the Sort1
After the sudden pause the program lost its credibility, many and I believe the majority of them (retail investors) felt burned sold and moved on. It will be an uphill struggle to get those folks back after many lost their hard earned money on their investment but as we know they didn't have a great deal of exposure from the start so now the job is to get more demand targeting as many investors as possible. The name change of the PDC is a starter and today they made a good effort to explain the logics behind the amended protocol. The perception of the protocol is failure and the ascribed value is negative. I read elsewhere the costs are over $20 million which is incorrect, folks talking about a study with good pre clinical but not working in the clinic which is not necessarily true. The company needs to make efforts explaining many things among others costs, timing, odds of success and financial rewards which is not zero as many believe. Sell it as an improvement of previous prtocol based on facts in hands with better probability of success and sell it to folks who have not been targeted, build a new base of believers. It's a restart so it should be branded as a restart. They have to deal with the scepticism of the program and sell it as a brand new protocol. I believe only then they can expect rejuvenated interest from investors. It's hard sell but absolutely necessary otherwise only good or great results will do the trick. No value/expectation and possibly negative value is included in the SP for an phase 1 clinical trial with potential good even great prospects which is not any shareholder friendly company with valuation at one times sales should ignore. So start the hard sell and keep it going. Try different ways reaching/ adding to Your audience.
Comment by
Smoky1 on Jun 13, 2023 8:05pm
Rebranding is important my favorite stock is TIO and confident it will beat the Hindenburg report ish.. Since @tingo_inc refutes the claim, there's been some positive sign and now I'm just adding up.
Comment by
Lee430 on Jun 13, 2023 9:12pm
I thought the presentation today was encouraging and I came away feeling cautiously optimistic after the many head fakes we have been through, felling like we have a good shot at POC and a potential blockbuster platform, however, We desperately need $$ so what’s the point of this presentation if Thera won’t make the effort to get it in the right ears?
Comment by
Joemare on Jun 14, 2023 8:13am
Another way to move the stock up with a P1 trial ongoing after being burnt once is to fast track the platform. So, they can start spitting out sort-1 with other target onco drugs in different cancer models. Or start releasing other sort-1 derivatives. I beleive Bicyle did that.
Comment by
Trogarzon on Jun 14, 2023 10:21am
It all comes down to the 2 million dollar man..... talk is cheap and now is the time to deliver on the parner front.
Comment by
jfm1330 on Jun 14, 2023 10:25am
They told us yesterday that in ovarian cancer, 75% of patients are overexpressing sortilin, so 25% are not. So statistically, it's at least one non responder just at enrollment, and if unlucky, it's easily two. That's the problem with this silly idea of not selecting patients on sortilin expression. I still don't get the idea and it's questionnable ethically.
Comment by
SPCEO1 on Jun 14, 2023 10:37am
If they are doing biopsies before starting treatments, what might be the purpose of those if not to determine sortilin overexpression. Why have they never talked about them before and what that info is used for? As pointed out by someone else earlier, the FDA specifically did not want to prescreen for Sortilin, maybe to see if all patients had some resposne because of free docetaxel?
Comment by
qwerty22 on Jun 14, 2023 11:52am
Let me summarize that rambling long post. Pre-screening or not prescreening is about two things. 1) Having data driven decisions versus decisions based on assumption. 2) The long term direction of the drug development process versus short term pressing needs. If you can think about the implication of those then the current decision looks much more viable.