Alzheimers Disease...........Every 72 Seconds
Every 72 seconds another person is diagnosed with Alzheimers!!
AZD-103/ELND005 doesn't just prevent the plaques seen in Alzheimers.....it Prevents Neuronal Cell Death as shown in this study. This Study is required reading for all Longs.....Puts into perspective the correlation between the COG Studies done and the Mechanism of Action........ https://www.jneurosci.org/cgi/content/full/27/11/2866#B44
Great quote here from Dr. Cruz........."Dr. Joanne Mclaurin (Inventor AZD-103) was looking at Neuronal Toxicity where Amyloid binds to Neuronal Cells and kills the Neuronal Cells and what she found was that if she added AZD-103 it PREVENTED the Neuronal Cell death. Then what she found was that to create Neuronal Cell death you need Fibrils (Oligomers) to come into contact with the Neurons. Just free Amyloid (Monomers) is not sufficient. What she found was that when she added AZD-103 was that it Broke Up the Fibrils." .......There we have the simplest explaination yet for AZD-103/ELND005.
McLaurins Findings were put to the test and taken a few steps further to find the Mechanism of Action when it was shown that AZD-103 completely REVERSED the Cognitive Impairment in a couple of separate but very different Cog tests...... one of which was run by Selkoe. So then in the Study 'Shankar et al 2007' with Dr. Selkoe showed that it prevents Synapes Loss!! Anyone that hasn't read this study really should. It shows that Monomers (regular Amyloid) DO NOT cause Neuronal Cell Death!! What it does show is that when Amyloid starts to Aggregate into Oligomers in the brain, specifically Dimers and Trimers in this study, that is when you can start to see the Neronal Cells Die and ultimately Synaptic Failure. This is when the memory starts going. Recall Transitions Affinity Column Study where it was shown that the Binding Affinity for AZD-103 increased with larger Amyloid Fibrils and then plateaued and all the while dissaggregated all sizes of Fibrils. MCI btw is estimated to be an even larger market than AD is......Perhaps 4 times as large.
Oh...... and when the Shankar et al Scientists introduced AZD-103.......well it REVERSED the effects that the Oligomers had on the Neuronal Cells and Dendritic Spine Loss and STOPPED Synaptic Failure in it's track. Bang !!
Merry Christmas ALL.....