RE: RE: RE: Anonymous? And another BBB player?Great posts guys, thanks for your research. Disrupting the BBB is not considered the best approach in delivering the drugs, but it is great to see they were able to get anti-β-amyloid antibody across. It will be interesting to see what was the actual increase in permeability and the actual increase in the drug uptake by the brain.
I found this brief helpful in understanding different approaches to crossing the bbb, including the disruption method and the vector mediated transport with receptors. This was written in early 2010 so they mention biOasis as still being in the poc stage: https://www.touchbriefings.com/pdf/3426/hoffmann.pdf
TB
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