Safest strategy is to WAIT for results first...then decide.This stock is a BINARY stock, meaning will be very volatile when results are released.
Best strategy is to wait for trial results before buying.
If trials fail, then stock will plunge and it will be trading in penny land, stock will be a dead stock for a very long time (5 years).
If the results are good and stock does jump, you can buy in knowing with confident that it will rally alot more higher no matter where it opens, because drug works.
If the results are inconclusive, like I think they will be, then stock will drop but as sharply and it is back to the drawing board, having to wait more years, so dead stock. Like 2 years to develop new drug and then years testing.
Plunge from $ 3.75 per share to $ 1.65 per share does not inspire confidence especially when it is very hard to keep trial results secret. Paralyzed people are either walking or they are not.
Also latest financing of PP was very telling, never a good sign to do it before results as it telegraphs to investors that you are not confident. Also some insiders were selling. Again shows a lack of confidence.
All in all, for myself I will wait for trial results.
I know I will pay more if results are successful, but I also know that I will pay for a stock knowing its direction.
If results are bad, then decision to stay out would have be a great one.
Be wise,
My personal opinion,
Good Luck to Everyone,