Soon to be news?Worth a look to what UHN has said about Theralase. Interesting to see that they have mentioned efficacy as well in the phase 1 clinical trial. Yes old news according to time line but hey have not changed or updated or edited it since then as of today about the efficacy!!!. So I will take that this is significant that there is a effcicacy report that will make a part in the Phase 1 clinical trial.. So i expect to see news releases about this in short order..Time will tell of course...
"On April 28th, 2016 the biotechnology company Theralase Technologies Inc. (Theralase) announced that it will extend its research partnership with UHN.
Theralase is a Toronto-based company that designs, develops and manufactures medical lasers to promote the healing of damaged tissues and the reduction of pain and inflammation. In parallel, the company develops new photodynamic compounds (PDCs), which are drugs that destroy cancer cells after being activated by a medical laser. In the past, UHN has worked with Theralase to conduct preclinical studies of new PDCs and medical lasers. Presently,
Theralase and UHN are partnering to evaluate the efficacy and safety of a compound known as PDC TLD-1433 in a phase I clinical trial at the Princess Margaret Cancer Centre. The new research agreement stipulates that Theralase and UHN researchers will continue to work together to evaluate the effectiveness of Theralase’s novel Ruthenium- and Osmium-based PDCs for the treatment of the lung, skin and brain cancers. UHN researchers will examine the new PDCs in a variety of experimental models of these cancers, and the most promising drug candidates will then be evaluated in clinical trials."
https://www.uhnresearch.ca/news/fighting-cancer-together
ALSO...Further to back up what I believe is that news will released about the three patients soon is what I found in the following. The next 6 patients will need to know before they participate in the new phase at a higher theraputic dose level..WOULDN'T YOU WANT TO KNOW BEFORE YOU SIGNED UP? I WOULD!
Clinical trials are closely monitored to ensure they are run in an ethical manner. Your rights and safety are protected through:
- Informed consent
- Careful review and approval of the clinical trial protocol by Health Canada, the hospital or clinic where the trial takes place, and the hospital or clinic’s research ethics board.
- Ongoing monitoring during the trial by Health Canada, the research ethics board and your research team
What is Informed Consent?
Informed consent is a process through which you learn the purpose, risks, and benefits of a clinical trial before deciding whether to join. It is a critical part of ensuring patient safety in research. During the informed consent process you learn important information about a clinical trial. This information can help you decide whether to join." (PEOPLE IN PHASE 2? My note here)
"The research team, which is made up of doctors and nurses, first explains the trial to you. The team explains the trial's:
- Purpose
- Tests and procedures
- Treatment
- Risks and benefits
They will also discuss your rights, including your right to:
- Make a decision about participating
- Leave the study at any time
Before agreeing to take part in a trial, you have the right to:
- Learn about all your treatment options
- Learn all that is involved in the trial - including all details about treatment, tests, and possible risks and benefits
- Discuss the trial with the principal investigator and other members of the research team
- Both hear and read the information in language you can understand
After discussing all aspects of the study with you, the team gives you an informed consent form to read. The form includes written details about the information that was discussed and also describes the privacy of your records. If you agree to take part in the study, you sign the form.
You can leave the study at any time, even after you sign the consent form. If you decide to leave the study, your doctor will discuss other treatment options with you.
Study Approval and Ongoing Monitoring
All clinical trials involving a new treatment or a different way of using a current treatment must be approved and monitored by 3 different groups:
- Health Canada
- The hospital or clinic where the trial takes place
- The hospital or clinic’s Research Ethics Board"
https://www.uhn.ca/PrincessMargaret/PatientsFamilies/Patient_Family_Library/About_Clinical_Trials/Pages/patient_protection.aspx
"Clinical Trials Follow Strict Guidelines
The guidelines that clinical trials follow clearly state who will be able to join the study and the treatment plan. Every trial has a person in charge, usually a doctor, who is called the principal investigator. The principal investigator prepares a plan for the study, called a protocol, which is like a recipe for conducting a clinical trial.
The protocol explains what the trial will do, how the study will be carried out, and why each part of the study is necessary. It includes information about:
- The reason for doing the study
- Who can join the study
- How many people are needed for the study
- Any drugs the participants will take, the dose, and how often
- What medical tests participants will have and how often
- What information will be gathered about participants"
https://www.uhn.ca/PrincessMargaret/PatientsFamilies/Patient_Family_Library/About_Clinical_Trials/Pages/clinical_trials_follow_strict_guidelines.aspx