RE:TLT clinical trail conundrumSome feedback to PhilDavis post: Some great points but I do take issue with some of them!
PhilDavis wrote: "TLT demonstrated absence of cancer recurrence in 2 out of 3 patients so far. Third is yet to be officially confirmed. Although I personally expect nothing short of cancer-free for him too, scientific, medical and broader financial community do not share a view of an enthusiastic TLT stockholder. They rely only on statistics (factual data)." SO WRONG!! As quoted from the news release! The three patients have NO RECURRENCE OF NMIBC so to me thats Cancer free! That is a fact and officially confirmed at the three month point!!
"The first three (3) patients have demonstrated no recurrence of NMIBC lesions at the ninety (90) day cystoscopy analysis." Not 2 but 3 are CANCER FREE! see news release below to reread! https://theralase.com/pressrelease/theralase-achieves-exploratory-endpoint-of-efficacy-for-anti-cancer-technology/
That is initself is amazing in itself since the three patients have already
FAILED THE CURRENT STANDARD OF CARE PREVOUS GIVEN TO THIS TRIAL!!! IM SURE THEY ARE VRY HAPPY TO HAVE THEIR BLADDERS!
PhilDavis wrote: "I will be so bold as to claim that the only reason TLT managed to get 3 out of 3 with half of therapeutic dosage is presence of induced immune response." This may have played a part BUT!
From the partnership with CiToxLAB for toxicology which will determine the following @ 2.55 of the youtube video. Hear RW talk about min and max dose and why they used CiToxLAB. - The minimum effective dose...
“The Study was designed to treat 3 patients at an initial dose of the PDC (0.35 mg/kg)” I believe that this is their minimum effective dose. - The Maximum effective dose...
“An additional six patients for the second part of the Study, treating them at a therapeutic dose of the PDC (0.70 mg/kg) for NMIBC.” I believe that this is their maximum dose! https://www.youtube.com/watch?v=PFC5GOZpx9I https://theralase.com/pressrelease/theralase-partners-with-citoxlab-for-toxicology/ They would have not have used the min dose if they knew nothing would come of it!
Alot of time and effort went into finding min and max doseage with Citoxlab!
They are not playing or trying to find min max dose in the trial they already know it.
PhilDavis wrote: "I would also like to ask you politely to refrain as much as possible from using “cure for cancer” term. It is in our best interest as longs. Here is why. As one highly unpopular poster noticed, “There isn't going to be a one size fits all cure for cancer in the near future. To believe otherwise undermines the diversity of the disease.”
Fair enough to not call it a cancer cure as of yet! You also stated that the unpopular poster noticed that we can address here is "it is not a once size fits all"
But on great thing and that is the very unique thing with TLD-1433 and the process is this and you may be missing is this.
This treatment is very patient specific regardless of cancer type! Because!
1) PDC's are considered black bodies, meaning it can be activated from Ultra vilolet to near Infrared. @ 14.20 to RW youtube video.
2) Can treat from 100 microns to 4 inches in depth!
3) Able to treat solid core hypoxic tumors ( with Type 1 and type 2 activation) such as breast, lung, prostrate, and bladder.
4) Has excelent selectivity and specivity.
5) Very patient specific through depth, penetration, and activation.
So it would be more correct to say it is one of "Diversity with slectivity and specivity for all cancers." instead of" "it is not a once size fits all". Flexibility, and Diversity, at its finest!!
https://www.youtube.com/watch?v=3Zz7CkBRDN8
That uppopular poster is just trying to confuse, misdirect, and create descension for what ever reason!
PhilDavis wrote:"As a blunt example I will give you liver’s inability to metabolise TLD 1433 in high dosage quick enough and possible consequences – if any." Since when does TLD 1433 need to be metabolised? I surely missed that. please provide a more detailed explanation with link reference for that please
!!!!! Here is RW saying this is benine until light activated @ 11:03 of the video.
He is also saying Safety and efficacy of PDC's @ 15:00 time line of video.
This is specific to treated area not liver!
https://www.youtube.com/watch?v=3Zz7CkBRDN8
"Proven safe in Good Laboratory Practice (“GLP”) pharmacology and toxicology studies" https://theralase.com/pressrelease/theralase-presents-dosimetry-planning-at-international-world-congress/
"The clinical evidence of the secondary outcome measure of PK demonstrated that the amount of TLD-1433 resident in plasma was less than 1 ng/ml after 24 hours and virtually negligible 72 hours post treatment. The amount of TLD-1433 resident in urine was less than 100 ng/ml after 24 hours and virtually negligible 72 hours post treatment.These clinical findings on the first 3 patients supported the conclusion of achievement of the secondary outcome measure of PK of the PDT treatment." https://theralase.com/pressrelease/theralase-presents-dosimetry-planning-at-international-world-congress/
RW has clearly stated in the past as to why these clinical studies are small
"small trials are used becaue of the dramatic results expected" and greater clinical trial studies subjects are used when the the expected results are not so great" PhilDavis wrote:As for grossly undervalued – not necessarily so. TLT demonstrated absence of cancer recurrence in 2 out of 3 patients so far. Third is yet to be officially confirmed. Although I personally expect nothing short of cancer-free for him too, scientific, medical and broader financial community do not share a view of an enthusiastic TLT stockholder. They rely only on statistics (factual data)
SO WRONG!!
As quoted from the news release! The three patients have NO RECURRENCE OF NMIBC so to me thats Cancer free! That is a fact and officially confirmed at the three month point!!
"The first three (3) patients have demonstrated no recurrence of NMIBC lesions at the ninety (90) day cystoscopy analysis." Not 2 but 3 are CANCER FREE! see news release below to reread!
Officail news release!
https://theralase.com/pressrelease/theralase-achieves-exploratory-endpoint-of-efficacy-for-anti-cancer-technology/
Undervalued absolutely udervalued!! Exceptonally undervalued in my opinion!
Just so hard to get my mind and oThers mind into really understanding to what that really means!
With what I have noted above it is in my opinion that having a process and product that can treat numerous cancer is priceless with an added POSITIVE SIDE EFFECT OF HAVING AND TEACHING THE IMMUNE RESPONSE ON HOW TO DEAL WITH THE CANCER CELL.
Good luck to all!