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Theralase Technologies Inc. V.TLT

Alternate Symbol(s):  V.TLT.WT | TLTFF

Theralase Technologies Inc. is a Canada-based clinical-stage pharmaceutical company. The Company is engaged in the research and development of light activated compounds and their associated drug formulations. The Company operates through two divisions: Anti-Cancer Therapy (ACT) and Cool Laser Therapy (CLT). The Anti-Cancer Therapy division develops patented, and patent pending drugs, called Photo Dynamic Compounds (PDCs) and activates them with patent pending laser technology to destroy specifically targeted cancers, bacteria and viruses. The CLT division is responsible for the Company’s medical laser business. The Cool Laser Therapy division designs, develops, manufactures and markets super-pulsed laser technology indicated for the healing of chronic knee pain. The technology has been used off-label for healing numerous nerve, muscle and joint conditions. The Company develops products both internally and using the assistance of specialist external resources.


TSXV:TLT - Post by User

Comment by enriquesuaveon Aug 01, 2020 10:06pm
174 Views
Post# 31354716

RE:RE:RE:RE:RE:RE:RE:RE:Theralase = TLD-1433

RE:RE:RE:RE:RE:RE:RE:RE:Theralase = TLD-1433

A small yet costly mistake. I'm surprised the PI Urologists didn't realize it. At last AGM Dr. Lilge was presenting on exactly this topic.  Perhaps since they had further optimized the hardware to double the power intensity maybe they thought that would compensate for not properly filling the bladder? Had we not undertreated, we would have possibly and most probably  gotten much better results.  Anything like 8 out of 12 or better CR would have probably sent SP soaring past $1.  This would have led to excercise of non trade able warrants and up to $10-12 Million extra in the coffers.  IMO  Not to mention the confidence it would show to all of the potential trial sites and patients in search of trial participation.  We can still catch up but will need to be very careful with next 12-18 patients.  Hopefully we can treat as many by December and do it right.
Some questions to possibly ensure success 
1) can we use red light as well as green light given high selective drug intake by cancer cells?  This would allow for treatment of hard to reach areas within bladder folds, or would properly or slightly overfilling bladder completely be sufficient?  Photofrin 60% and Radachlorin 90% 12 months CR
2)Do they also instill bladder to maximum bladder capacity?  As this will provide for accurate drug quantity.
3)Can they retreat 4 patients dropped from trial given new protocol?
4)Is it better to slightly over treat given high drug selectivity and hence achieve maximum efficacy while maintaining high safety?
While it is frustrating to see what's happened, it may allow for us to get more shares cheaper and eventually pay off big time?  I sure hope so.  We will need lots more patience IMO, but should hopefully get there in the end.
All IMO  GLTA


Eoganacht wrote: Theralase has admitted the errors were on their side. How this could have happened I don't have the slightest clue. But I don't buy that the doctors sold out their patients for cash payments and then, for some reason, Theralase took the blame.

LaserStock29 wrote:
Eoganacht wrote: So thadeush - you think Dr. Kulkarni and/or Dr. Kassouf were bribed by "big pharma" to sabotage the treatment of the critically ill cancer patients in their care. And then the ever-obliging Theralase covered for them by publicly stating that the problem was not with those running the trial but with the clinical protocol that was submitted to them by the company. I guess big pharma also bribed Theralase to sabotage their own trial.
thadeush wrote: I know they're probably monitoring the testing meticulously and I hate to bring this up, but the conspiracy part of my personality thinks that the success of TLT's Phase 2 might bring quite a bit of pain to the stock price of other treatments. Is it possible that any of the doctors doing the test could have been 'incentivised' by some large pharma groups to alter the doses and throw off the results? I doubt they'd be able to get away with altering the likely much more closely watched second treatment, but things are pretty ruthless when this kind of money is involved. I only bring it up because the results seem like such an anamoly.

 


Consider all the dosimitry work done by Dr.Lilge et al... eliminating meticiously one objection at a time... the ability to measure light.. incidence and refractory.... 'bouncing off the luminal layer'  automatically calculated by a computer...  Monte Carlo then the upgraded Full Monte. etc


Then consider 2016 AGM   9:40

2016 Agm


Then consider 2016 AGM mark

2016 AGM Dosimitry Avoiding Overtreatment and Undertreatment 13:47


Im sure science is difficult and once you get to actually do things in life... sure a curveball here or there can happen.. But im sorry... There was 1 month between patients one and two (March 3 and April 7) for which we were told via NR.

Are we to believe that Dr.Lilge wasn't emailed, cc'd or forwarded the dosimitry......
"Hi Dr.Lilge, here is the data from the first patient, can you check and confirm that the dose is accurate to the projected modelling of patients bladder by the computer system.. is this patients bladder sufficiently 'treated'   and not over/under treated.

This inter-phase 1 review was done and we experienced a 6 month delay between patients while we 'Optimized' the treatment further.....  so why wasn't that same consideration done for Phase 2?   Again considering so much time was between patients.   It's not like we rattled off 10 in a week and could say whoops...... look at that... no time to make an adjustment.

Man oh man........ I try to be as rational about these things..... and not conspiracy oriented..... but I dont like the incomplete report we were given..




Lets put it this way just read what was the Late 80's and Early 90's on Photofrin.. the numbers around this..

1993 Trial Photofrin Japan


2004 Quebec Review of PDC PDT


Then consider Dr.Wilson

Photodynamic Therapy Review 2011


In my mind it's not possible to have results like this worse than photofrin......  it seems fishy as fuc*




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