Theralase Technologies Inc. V.TLT

Alternate Symbol(s): V.TLT.WT | TLTFF

Healthcare Medical Devices

Theralase Technologies Inc. is a Canada-based clinical-stage pharmaceutical company. The Company is engaged in the research and development of light activated compounds and their associated drug formulations. The Company operates through two divisions: Anti-Cancer Therapy (ACT) and Cool Laser Therapy (CLT). The Anti-Cancer Therapy division develops patented, and patent pending drugs, called Photo Dynamic Compounds (PDCs) and activates them with patent pending laser technology to destroy specifically targeted cancers, bacteria and viruses. The CLT division is responsible for the Company’s medical laser business. The Cool Laser Therapy division designs, develops, manufactures and markets super-pulsed laser technology indicated for the healing of chronic knee pain. The technology has been used off-label for healing numerous nerve, muscle and joint conditions. The Company develops products both internally and using the assistance of specialist external resources.

TSXV:TLT - Post by User

Theralase Technologies Inc. > Theralase Updated Website!!!!

<< Previous

Bullboard Posts

Next >>

Comment by Eoganachton Oct 17, 2020 6:45pm

223 Views

Post# 31735129

RE:RE:RE:Theralase Updated Website!!!!

Dr. McFarland published a good article in 2018 on the details of immunogenic cell death during apoptotic cancer cell death. Like you write, there is ample evidence that pdt with TLD1433 induces ICD.

Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy

Hempdoc wrote:

Eoganacht wrote: Thanks for that Jaro1977. Theralase did a nice job on the update. This visual says it all!

NMIBC STUDY DRUG TLD-1433

TLD-1433 Mechanism of Action

Jaro1977 wrote: Very nice! Check these pages out;

https://theralase.com/anti-cancer-therapy/pipeline/

https://theralase.com/anti-cancer-therapy/research-publications/#publications

The beauty of our PDT is that it not only causes efficient cancer cell death primarily by apoptosis (a pathway which leads to less localized inflammatory side efffects/toxicity), it neatly generates damage-associated molecular patterns (DAMP), which elicits a favorable anti-tumor immune response.

Dendritic cells (DCs) are our immune system's sentinels that can be pulsed/co-cultured (or take a bath together with tumor antigen or DAMP) to produce DCs "highlighted" with tumor antigen...larger "Eat Me" signal...and why I thought pulsing DCs with porous nano silicon (acts like a sponge & soaks up lots of antigen) could also provide a delicious Eat Me signal.

We have now reached the point where "multiple" studies looking at "multiple" cancers have shown that vaccinating mice with PDT-treated cancer cells (containing DAMP) with or w/o pulsed DCs induces "potent" immunity against cancer cells. Additionally, vaccinating "naive" mice has been shown to provide complete protection against cancer cells of the same origin or type (2015 squamous cell cancer study). Key takeaway: a healthy "systemic" anti cancer immune response was induced.

I believe TLT plans to take full advantage of this very realistic opportunity to bring the above cancer vaccination strategy to a new level of personalized immunotherapy, one which maximizes safety & excels in the treatment & prevention of both cancer & infectious disease...So much potential with PDT & our PDCs. Good luck....