Theralase Technologies Inc. V.TLT

Our possible next indication target ?

[Oden6570]

Development of efficient photosensitizers that can more specifically target cancer cells, and approaches to deliver light that can penetrate large or deep tumor tissue should be developed. Photosensitizers conjugated with specific nanoparticle platform could be developed for better penetration. Moreover, nanoplatforms functionalized with specific receptor-based detectors such as antibody constructs, monoclonal antibodies, or small molecules inhibitors could improve lung cancer cell-specific delivery of photosensitizers [34]. The design of innovative equipment to improve the delivery of light sources is urgently needed for the higher efficacy of PDT in large or deep lung cancer. Pieces of literature have suggested that PDT triggers the immune response to control local and metastasized cancer. The beneficial role of intraoperative PDT on mesothelioma patients might be via modulation in immune response [90]. Therefore, the development of a novel combination of PDT and immune checkpoint blockade therapy could be beneficial for metastatic lung cancer [91]. Recently, Yang and colleagues developed a sequential PDT and photothermal using Gd-Ce6@SWNHs platform with cooperative and long-lasting antitumor immune responses for the treatment of patients with advanced metastatic cancer [92]. The application of novel PDT platforms, nanoparticle-based photosensitizers, and improved imaging and surveillance system is crucial to improve the efficacy of PDT in lung cancer treatment.
An update in clinical utilization of photodynamic therapy for lung cancer (jcancer.org)