RE:RE:RE:RE:BTD I agree Enrique...
Any persistent/prolonged IR is an indication to me that the cancer is being held in check for the most part, which I'd consider a reasonably good outcome for a cancer that has such a high risk of progression. My guess is the immune response triggered by our treatment is not only holding these IRs in check, but the response may also become more robust over time, thereby increasing the chance of an IR reclassifying to a CR.
It will be very interesting to see what percentage of IRs become CRs. Such knowledge would help our understanding of what an IR could mean (i.e. be a positive indicator of a good clinical outcome or at least play a prognostic role)...and closely following the temporal evolution of an IR to a CR (or an NR) would not only add to its potential prognostic value, but it would also provide some insight on whether an additional treatment is warranted & what would be the best time to give it. All imo. Good luck...