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Theralase Technologies Inc. V.TLT

Alternate Symbol(s):  V.TLT.WT | TLTFF

Theralase Technologies Inc. is a Canada-based clinical-stage pharmaceutical company. The Company is engaged in the research and development of light activated compounds and their associated drug formulations. The Company operates through two divisions: Anti-Cancer Therapy (ACT) and Cool Laser Therapy (CLT). The Anti-Cancer Therapy division develops patented, and patent pending drugs, called Photo Dynamic Compounds (PDCs) and activates them with patent pending laser technology to destroy specifically targeted cancers, bacteria and viruses. The CLT division is responsible for the Company’s medical laser business. The Cool Laser Therapy division designs, develops, manufactures and markets super-pulsed laser technology indicated for the healing of chronic knee pain. The technology has been used off-label for healing numerous nerve, muscle and joint conditions. The Company develops products both internally and using the assistance of specialist external resources.


TSXV:TLT - Post by User

Comment by CancerSlayeron Mar 15, 2023 12:39am
285 Views
Post# 35338952

RE:About the addition of up to 9 CSS ...

RE:About the addition of up to 9 CSS ...

SF wrote:  


"These "up to 9 new sites" could also be because the FDA wants 125 patients, instead of only 100, considering the 12 undertreated patients, in order to have a better picture.  But even there, even with these 12 undertreated patients, we already have excellent numbers (28% CR and 38% TR), despite them representing 41% of our 29 evaluable patients (12 NR out of 29 evaluable patients)."

 

I believe the FDA would want a more representative sample of patients treated (i.e. a total of 125), especially considering 10% of this total will have been undertreated.  

When looking at the durable response numbers in those Ph 2 patients who received "two optimized" treatments (patient 13 & on), the 450 day CR is 35%.  If you add in the two Ph 1 patients who received a single optimized treatment, the 450d CR rises to 47%.  

The above suggests that optimization helps, but hypothetically, more treatments may not always translate into better outcomes across the board.  Imo, the key for any successful treatment is to pack a big punch at the beginning, which our ACT attempts to do at the molecular level & is thus far doing relatively well...multiple weaker/ineffective punches (or too many of the same punches) could not only potentially lead to more side effects, but also more treatment resistance (I.e. a weaker punch(es) can unintentionally encourage the growth of more resistant cancer cells).  You can see this resistance happening repeatedly in oncology wherein a highly-focused treatment attacks a single target/checkpoint.  When such a highly-targeted treatment is performed over & over & over again, such a serial approach may actually promote a more aggressive cancer & metastasis.

The big reason I invested in this tech is because TLT is approaching cancer treatment from a more universal (a one mechanism fits all) perspective.  And in those cases where more is needed, you can combine the better/best option with the lesser one...all imo.  

I am still thinking the 9 new sites in "2023" has some connection with a friendly partner/funding...& possibly grant help.  There is "a lot" of pressure at both federal & state levels for the FDA to perform its obligation in providing the public not only safe & effective treatment options in a timely manner, but also optioms that are both patient & pocket book friendly.  This is only a matter of time in my analysis...

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