Theralase Technologies Inc. V.TLT

more competition for TLT

[riverrrow]

https://au.finance.yahoo.com/news/successful-test-cancer-killing-drug-115734679.html

[DJDawg]

Interesting article for sure. Usually when they are testing a drug on zebrafish it is fairly early in the IND enabling work. It might be competition but so many more steps to happen over many years.

[gebremeskel]

TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models Published online 2020 Mar 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139549/

[socksnblonds642]

There was more info on what a Trosian horse is than what their compound is so I think it's safe to say they are a ways off from Theralase IMO. TLD1433 results will drive everything. It doesn't matter if there are 2 or 3 or 6 other competitors. Unfortunately the market is big enough to support all solutions. Hope they all work. So we just become rich instead of stinking rich. 

[gebremeskel]

You want info? Here's their patent. They are still a long way off from human trials. It works a lot like TLD-1433 except that it gains access to cancer cells by binding with metabolites (sugar and amino acids) rather than transferrin (iron) and it is extremely small, so it can cross the blood-brain barrier. https://patents.google.com/patent/WO2020187913A1/en Inventor   Marc

[Pandora]

"The compound of the invention can be used in photodynamic therapy for ablation of metabolically-active cells. Once the labelled metabolites are uptaken by the target cells, their activation with visible light leads to singlet oxygen generation and concomitant cell death." "The compounds of the invention can also be used to label cancer cells, immune cells as well as stem cells

[Eoganacht]

More detailed info : Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062536/#MOESM8

[BlueFranky]

Eoganacht. Great to see you back!

[Mikee3003]

Thanks Eogan, always look forward to the informative research you provide to this board. Please keep up the great work. Thanks, Mikee

[gojotv!]

Thanks for the laugh, riverrow. They've got years of testing and research to do. And they'll need to partner up with laser device company before they can even begin trials. And I'm not too hopeful for their chances of success, since they release a toxin in cancer cells to kill them, where TLD-1433 kills cancer cells with oxygen... much safer for the body. Two possibilities: This one