Theralase Technologies Inc. V.TLT

Matthew Perraton GBM Update from Jan 2 email

[Eoganacht]

Theralase® Non-GLP Toxicity Analysis for Brain Cancer

 

Theralase® is forwarding a summary of the preclinical data to Health Canada for review and response on a GLP toxicology program to be completed by the Company by Q1 2024.

 

Based on the successful completion of the GLP toxicology program, Theralase® intends to commence a Phase Ia/Ib dose escalating clinical study in 2024 in patients diagnosed with GBM to determine the appropriate clinical dose of the drug from both a toxicity and tumor localization perspective. 

 

This phase will also look at radiation activation of a single IV dose of Rutherrin®.

 

Following the successful completion of the Phase Ia/Ib clinical study, Theralase® plans to commence a Phase IIa/IIb clinical study in Canada and the United States focused on enrolling and treating patients diagnosed with recurrent GBM, with multiple radiation activated doses of Rutherrin®.

[DJDawg]

Thanks for posting Eog. There is some very interesting stuff here. For those that are not aware the way you evaluate solid tumours is different that non-solid and bladder. It all comes down to special criteria called RECIST. You treat and then you calculate any drop in size of the mass (GBM here) and a certain amount is considered real. With a lot of newer cancer agents, you take a drug regularly

[Longholder99]

Great info Dawg and Eog.  Thanks 

[Eoganacht]

Very interesting post Dawg. It may be that all that can be hoped for is to give GBM patients more time before they succumb to the disease. It's a horrific prognosis. Adult GBM patients treated with chemo and radiation have a median survival of 14.6 months and a 2 year survival rate of 30%. But we really don't know how effective repeated treatments activating systemically administered

[patience69]

Amazing posts & topics guys. I am the biggest bull going but the million dollar question remains. Where & when do we get the money to pursue it. I think that it is fair to say that this has been discussed for years (2017 news release ) however to the best of my knowledge money has held us back. Are we confident that this is changing soon? Lets hope

[fecats]

At the end of the day everything in this world comes down to money. We simply don't have enough to move anything else forward. I think we are far enough along on NMIBC that we should be able to attract  money in a different way than just pp. I trust mgmt is exploring other ways to raise money such as a JV or royalty deal . I am confident we have enough to be attractive at this point

[Oilminerdeluxe]

No doubt, they are exploring other ways of finding money. But it would be much easier with BTD in hand. I suspect that any deal would require many, many months to negotiate. Maybe that has been going on, but how strong could their hand be? BTD should at least make it stronger. Timewise, it could be grueling long to wait still if those supposed negotiations have not started for real with interested

[Alamir1111]

Interesting is that tlt is collaborating more with HC getting response and approval like third dosing for nmibc now gbm.like it

[Oilminerdeluxe]

Having two studies going would be sweet. Should boost us. With a little luck, the pre-Btd could be sent in by now