Yosprala a possible AD med --trillion plus $ market size!! I have been more familiar with Aspirin's benefit to the human cardio system, and had only briefly heard of the possibilities for the CNS treatments...I just came across a new article talking about the 4 top possible MOA's and different approaches that could treat CNS and specifically AD.... a massive untreated market... Below is the quote on what was said about AD and Aspirin... (BTW not only is the AD and CNS market massive, and world wide in the Trillions, but equally important there is almost zero competition, and the bar for approval as a result is very low, the current SOC for Ad does not reduce at all it only barely slows progression)
"NSAIDs have been thought possibly to slow the onset of AD, or, possibly, to delay disease progression. The basis for this thinking has been the intuitively reasonable supposition that inflammation plays a role in AD, and that NSAIDs, active against inflammation, could counter AD. However, a large controlled trial – the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT) in more than 2,000 subjects, reported contradictory results. In persons with symptomatic AD, who represented a small fraction of the 2,000 subjects, NSAIDs appeared to increase the risk of AD progression more than placebo, while in asymptomatic persons, one of the trial NSAIDs (naproxen) appeared to delay the risk of onset, after about 3 years of treatment. The bottom line is blurry; it can’t be said for sure whether NSAIDs help or hurt, but they are for sure not the magic bullet.
Aspirin has a number of mechanisms that the other NSAIDs don’t share. In addition to being an anti-inflammatory and analgesic, aspirin acts to prevent the formation of blood clots and also lowers fevers. Aspirin has been reported to improve cognitive function in some subjects, but there’s no evidence that it slows or prevents the onset of AD. Salicylic acid (aspirin is acetylsalicylic acid) has been reported to bind with an enzyme called GAPDH which is thought to contribute to cell death; when salicylic acid binds with GAPDH the resulting particle can no longer pass the blood-brain barrier. Thus, aspirin may possibly prevent cell death in the brain. The objective of further research would likely be finding a way of delivering the supposedly beneficial salicylic acid effect without incurring the bleeding risk that would accompany high dose aspirin."