Internal vs. External testing efficacy
Scientific publications are done by external parties, external researchers but funding comes from TLN.
Before testing externaly, TLN does it internally,.
Thisi is what I got about 4601 possible efficacy based on internal data (from listening to webcast).
Management said in news conference that they tested a biomarker establishing beyond doubt that 4601 is a powerful lingand to PBR.
Also, they managed with Caprion's participation to establish Ras Pathway blocking 'downstream that is".
PI also indicated no toxicity and no max dosage.
So, far 100% of the mecanism of action is proven.
Now the drug should work if you postulate that the sum of all parts = positive results. All the small parts have been proven to be ok, now PII results will give evidence of the whole motion picture working accordingly to model.