Talen Energy Corp V.TLN

Primary Symbol: TLN

Talen Energy Corporation is an independent power producer and energy infrastructure company. The Company owns and operates approximately 10.7 gigawatts of power infrastructure in the United States, including 2.2 gigawatts of nuclear power and a significant dispatchable fossil fleet. It produces and sells electricity, capacity, and ancillary services into wholesale U.S. power markets, with its generation fleet principally located in the Mid-Atlantic and Montana. Its PJM segment is engaged in electricity generation, marketing activities, commodity risk and fuel management within the PJM RTO or ISO markets and comprises Susquehanna and its natural gas and coal generation facilities. Its Other segment includes the operating and marketing activities of Montana’s proportionate share of the Colstrip Units in the WECC market, the operating activities of Nautilus, and other development activities. It owns 100% of Nautilus Cryptomine (Nautilus), a 200-megawatt bitcoin mining facility in Berwick.

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Talen Energy Corp

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Post by everswannon Mar 05, 2009 10:35am

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Post# 15822598

p53 in pretreated patients and 4601

It is my understanding that p53 is mutated and stop responding to Temozolomide due to MGMT level.

In a nutshell, in mutated p53 AKT activation is an alternative pathway and no apoptosis occurs.
4601 should be effective in mutated p53. Mutated p53 are indenpendant of MDM2 inhibition effect, they seem to be always inactive.

Also, wild type p53 (cancerous p53) activition is closely dependant on MDM2.
4601 directly reduces MDM2 level by shutting down AKT.

So far very encouraging reading.

Will completed DD on p53 later.

Cheers.

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