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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

Bullboard Posts
Comment by firesIayer96on Aug 14, 2013 12:07pm
221 Views
Post# 21669613

RE:RE:RE:RE:OVARIAN CANCER UPDATE

RE:RE:RE:RE:OVARIAN CANCER UPDATE
A bit of digging around this morning puts my best guess at Takeda. https://www.takeda.com/

Dr. David Huntsman has previously worked closely with Dr. Cashman.

Check out this NR from a few years ago announcing a collboration between BCCA and Takeda.


https://www2.news.gov.bc.ca/news_releases_2009-2013/2010PREM0110-000585.htm

From today's NR:

These studies were performed using the ES-2 ovarian clear cell carcinoma (OCCC) tumor model. Clear cell carcinoma accounts for 5-13% of ovarian cancer cases in Western populations and 15-25% of cases Japan. OCCC has been shown to be associated with a poorer prognosis and is relatively resistant to conventional platinum-based chemotherapy when compared to other types of ovarian cancer. Thus, there is a great need for novel OCCC therapies.

From the 2010 NR announcing collaboration between BCCA and Takeda:

“This unique partnership will focus Takeda’s drug development capacity on specific abnormalities identified in ovarian cancers,” said Dr. David Huntsman, director of the ovarian cancer research program at the BC Cancer Agency and Vancouver Coastal Health Research Institute, and professor, department of pathology and laboratory medicine, UBC. “We need new approaches to treat the many subtypes of ovarian cancer and we look forward to working with Takeda scientists to translate our genomic discoveries into better outcomes for women with this cancer.”

Just something to mull over. Thoughts?
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