RE:RE:RE:Screening out UUTUC...wildbird,
This is a clinical trial to treat NMIBC...according to the criteria for inclusion, metastasis is specifically excluded, since that would entail treatment of MIBC...the phrase "worst of the worst" as it applies to these patients means those who have no prospect of saving their bladders utilizing SOC treatment for NMIBC, not that they have metastasis...
As far as vestor's question regarding treatment of patients with UUTUC outside the treated area, that does not mean that metastasis has occurred, only that the applied treatment doesn't reach the region outside the bladder but still within the upper tract...the PDT might well be infused in the upper tract, but the treatment in the ureters and into the kidneys' catch basin (all of which have the same surface layer) cannot be applied since the light source, as currently configured, cannot reach those areas...