Liminal BioSciences Inc. PFSCF

last two patents by Prometic

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• Substituted aromatic compounds and pharmaceutical uses thereof

  Patent number: 9938221

  Abstract: The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.

  Type: Grant

  Filed: December 8, 2014

  Date of Patent: April 10, 2018

  Assignee: PROMETIC PHARMA SMT LIMITED

  Inventors: Boulos Zacharie, Christopher Penney, Lyne Gagnon, Jean-Francois Bienvenu, Valrie Perron, Brigitte Grouix

• SUBSTITUTED AROMATIC COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, LIVER FIBROSIS,SKIN FIBROSIS AND CARDIAC FIBROSIS

  Publication number: 20180134649

  Abstract: The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, OH or F; R2 is H, OH, F or CH2—OH; R3 is H, OH, F or CH2Ph; R4 is H, OH or F; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH.

  Type: Application

  Filed: December 22, 2017

  Publication date: May 17, 2018

  Inventors: Lyne GAGNON, Pierre LAURIN, Brigitte GROUIX, Lilianne GEERTS, Franois SARRA-BOURNET, Martin LEDUC