Brutal!!God Almighty what a brutal day!! ACST continues to erode daily from its highs of a few weeks ago and the other bio I have, ATE, just announced that its critical Phase 2 results expected early September will be delayed a couple of months. An investor in these types of companies is challenged on two fronts. Firstly its the nature of the companies themselves always raising money, the high risk of trial failure, long timelines, management stuffing their pockets with options, etc.. Secondly is the nature of many of your fellow investors whether they are an algorithm, momentum traders, people looking to skim a few percent and move on, people with inside info, manipulators, the impatient etc... they make the share prices so volatile. But then big gains in these types of stocks are not realized without some severe shareholder pain I guess. In the case of both ACST and ATE, despite current share price weakness, both stories are still intact. I will take a position and wait for the stories to play out. I don't know how else to best realize the potential share price appreciation of each of these companies.