From previous news release on March 09 Mr. Rae commented "I want to thank the entire iCo team for their enormous dedication to both product candidates in development. It has been an incredible experience to work with this world-class team. Given the recent partnership announced with Alexion and a positive primary Phase 1b endpoint for oral Amphotericin B, I look forward to seeing further upcoming development milestones for both assets".
iCo recently completed a Phase 1b Oral Amphotericin B study in which subjects were dosed for 10 consecutive days with additional 10 days of follow-up (for a total of 20 days), with a positive primary endpoint achieved. Two doses of Oral Amp B (100mg and 400mg), showing promising pharmacokinetic outcomes in the previous Phase 1 trial (using a single dose only), were used in the Phase 1b study. Currently the Company is planning for a Phase 2 study.