RE:RE:Animal trialsOnly proven safe when used by instillation so far ... not when taken by mouth or injected intravenously or intramuscle ... have to show where it goes, where it collects, where it sequesters, how long it takes to exit the body, what effects there are on various organs and systems in the body, etc. ... can't just skip ahead. That's why they have to plan for a Ph I for each new indication; e.g., GBM and NSCLC.