RE:RE:RE:RE:Fireside Chat on August 10Paul is the CEO so, as Harry Truman said, "the buck stops here". I am not sure why you try to put words in our mouths. No one made the claim TH's management was dumb or incompetent. The only claim was they did not do a good job of keeping the market informed about the big miss on the timing of the phase 1a and there is not really any controversy about that fact. I don't typically vote against management - it's just not part of our DNA. But I don't really think you or anyone else believe anyone should vote management out just based on missed drug trial timelines. If so, there would be massive management turnover in the drug industry. Maybe the best strategy for you when vacationing is just to skip reading JFM's posts. Enjoy the beach!
palinc2000 wrote: Ok so it was the company 's timelines.... Where did the company get the original timeline? From Paul ?
I doubt that ! The problem with your friend is that he originally said that the reason scientists were not sold on TH1902 was that it was too simple and not complexed enough ....and he also was hoping for miraculous results just a few months after the initiation of Phase 1 a....That was HIS timeline.
Of course he never accepts being wrong and his need to blame others takes over...
We all remember the calls for Christian to wake up and the same to Paul and he still blames the company for a flawed Phase 1 trial design
You are now also implyimg that the Company was somehow incompetent in predicting the time lines for Phase 1 a .... Why are you voting the shares you control for such dumb management?
P,S
My previous post was written on a sandy beach with a glaring sun in between swims in the beautiful ocean with dirty sun glasses .... I did not think that spelling errors bothered you.... I will not post on sunny days outside any more
SPCEO1 wrote: Some thoughts on your comments:
1.) The timelines the company originally gave were way off the mark for 1a. That is just a fact and the company did not do a very good job of updating the market in a timely manner about the delays.
2.) The whole point of a phase 1a dose escalation trial is to push the dosage levels up to the point where you have side-effects. So, that is the plan from the get go - find just how far you can push it. Also, mice cannot talk, so they have a hard time reporting on some side-effects!
3.) I don't think we really know what delayed the phase 1a. Since the goal is to find a dose that causes problems and then step back to a lower dose, that should not have caused any delay. Maybe one day we will know what caused the delay but my best guess is a debate about whether the problems at the 420mg level were big enough and constant enough across patients to stop there.
4.) Not that I have any standing on this subject, but your spelling really falls apart when you reply to JFM, reflecting your long term animosity for him getting the best of you. He made a simple and factual point about the really bad predictions Paul made about the time it would take to complete the phase 1a and you responded with a whole bunch of other heated, mis-spelled stuff.
As Rodney King once famously asked in the midst of rioting in Los Angeles - "Can't we all just get along?"