RE:ONCY's pelareorep involves direct dendritic cell activation Dendritic cells act like the generals of the immune system waking up other immune cells such as T cells and telling them what to attack and the weapons to use. However, cancer cells are very good at hiding from the immune system.
By combining pelareorep with immune checkpoint inhibitors, the cancers become visible to the immune system and the reovirus activated dendritic cells go to work and ‘organise’ the T cells to kill the cancer.