RE:RE:RE:RE:RE:ONCY pelareorep + CD3 bispecific antibody true-killer combo Preconditioning the tumor microenvironment with oncolytic reovirus resulted in the activation of immunologically cold tumors, explained the researchers. This in turn led to more successful engagement of bispecific antibodies, causing tumor cell death.
https://absoluteantibody.com/general/using-bispecific-antibody-reagents-to-further-research/
ONCY's oncolytic virus facilitates CD3 binding while it "primes" the immune system for both an innate and adaptive immune response to the tumor cells and models the tumor microenvironment (TME) towards T-cell activation and the minimization of T-cell exhaustion.