RE:AEZS's diagnostic test:Bing:
Aeterna Zentaris has developed a growth hormone deficiency (GHD) test using macimorelin, which offers several advantages compared to traditional GH-stimulation tests:
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Simplicity: The macimorelin test is straightforward and easy to administer. It involves oral administration of macimorelin to the child, followed by blood sample collection within 60 minutes. In contrast, other GH-stimulation tests often require more complex procedures.
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Minimal Side Effects: Macimorelin is well-tolerated with minimal side effects. This makes it a more comfortable experience for patients, especially children.
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Fewer Blood Draws: Unlike other tests that may involve multiple blood draws, the macimorelin test typically requires only 3 to 4 blood samples. This reduction in blood draws is beneficial for both patients and healthcare providers.
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Shorter Duration: The entire process, from administration to blood sampling, is completed in a shorter time frame. This efficiency is advantageous for diagnosing GHD promptly.
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Accurate Diagnosis: By measuring growth hormone levels in blood samples, the macimorelin test allows for the determination of GHD based on a predetermined threshold value. If the peak growth hormone level falls below this threshold, it indicates pituitary-related GHD.
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Treatment Option: The patent also covers treating the deficiency with synthetic human growth hormone, providing a comprehensive approach to managing GHD.
In summary, Aeterna Zentaris’ macimorelin test offers simplicity, minimal invasiveness, and accurate diagnosis, making it a valuable alternative to traditional GH-stimulation tests123
prophetoffactz wrote: Macimorelin is the first and only US Food and Drug Administration (FDA)-approved oral drug indicated for the diagnosis of adult GH deficiency (AGHD), a rare endocrine disorder. In clinical trials, macimorelin demonstrated comparable diagnostic accuracy to the gold standard GH stimulation test, the insulin tolerance test (ITT) [4]. Potential advantages of macimorelin over the ITT include better tolerability and greater convenience. Macimorelin has no absolute contraindications [1], unlike the ITT, which is contraindicated in elderly populations and in patients with cardiovascular disease or seizure disorders [2,[5], [6], [7]].Safety, tolerability, pharmacokinetics, and pharmacodynamics of macimorelin in healthy adults: Results of a single-dose, randomized controlled study - ScienceDirect