RE:RE:ONCY's pelareorep activates TiLs (CD8+ Dendritic Cells) Reovirus (pelareorep) studies have also demonstrated that the PKR- and NF-κB-dependent induction of pro-inflammatory molecules (i.e cytokine response molecules) that accompanies reovirus-mediated killing can recruit and activate innate and adaptive effector cells [such as macrophages like natural killer (NK) cells, dendritic cells (DC) and cytotoxic T cells (CTL))] thus altering the tumour microenvironment (TME) to support bystander immune-mediated therapy as well as direct viral oncolysis, and through the 'remodeling' and 'priming' of the TME in advance of the addition immune checkpoint inhibitor therapy.
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-10-20