COSCIENS Biopharma Inc T.CSCI

Juvente PGX-OBG/Avenanthramide: Wound healing & ageing skin

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Based on the research findings, a cream containing PGX oat beta glucan impregnated with avenanthramide could potentially be very effective for wound healing and skin health:

Wound Healing Benefits

The combination of avenanthramides (AVN) and beta glucan (BG) showed promising results for accelerating wound closure and improving healing quality:

• AVN reduced inflammation and scarring, leading to tissue that more closely resembled normal skin architecture.
• BG increased angiogenesis (formation of new blood vessels) and improved collagen fiber structure.

A topical cream formulation could potentially deliver these benefits effectively, as beta glucan has been shown to penetrate to deeper skin layers.

Anti-Aging Potential

This formulation may also provide anti-aging benefits for skin:

• Beta glucan acts as a natural moisture barrier and film-forming agent.
• It smoothes wrinkles and reduces visible signs of aging.
• Beta glucan relieves dry and itchy skin by replenishing the skin's moisture barrier.

Advantages of PGX Technology

Ceapro's PGX (Pressurized Gas eXpanded liquid) technology offers some key advantages:

• It produces a highly purified liquid beta glucan.
• The resulting product is non-GMO, allergen-free, and not tested on animals.
• PGX allows for the potential impregnation or encapsulation of bioactive compounds like avenanthramides with beta glucan.

Potential Effectiveness

While the original study used injections, a topical cream using PGX technology could still be highly effective:

1. Deep Penetration: Beta glucan can deliver compounds to the deepest levels of the skin, potentially mimicking some benefits of injection.
2. Synergistic Effects: The combination of AVN and BG showed complementary benefits in the study, which could be preserved in a cream formulation.
3. Ease of Use: A topical cream would be much more convenient for regular use compared to injections, potentially improving compliance and long-term benefits.
4. Versatility: This formulation could address multiple skin concerns simultaneously, from wound healing to anti-aging.

While clinical studies would be needed to confirm the efficacy of a topical cream compared to injections, the existing research suggests that a PGX oat beta glucan cream impregnated with avenanthramide has significant potential for both wound healing and anti-aging applications.

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