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Thiogenesis Therapeutics Corp V.TTI

Alternate Symbol(s):  TTIPF

Thiogenesis Therapeutics, Corp. is a Canada-based clinical-stage biopharmaceutical company. The Company is developing sulfur-containing prodrugs that act as precursors with the potential to treat serious pediatric diseases with unmet medical needs. The Company’s lead compound, TTI-0102, is a disulfide, made up of two thiols that lead to two independent cysteamine molecules. Cysteamine is a thiol that has been rigorously studied and tested. It is the active ingredient used in drugs to treat the lysosomal storage disease - (nephropathic) cystinosis. TTI-0102 has been developed to address the obstacles facing thiol-based drugs, their short half-life, gastrointestinal (GI) side effects and dosing limitations. As a prodrug, TTI-0102 is metabolized into cysteamine molecules after it is ingested. The metabolic process acts as a gating mechanism. TTI-0102’s initial applications are for MELAS, Leigh syndrome, Rett syndrome and pediatric non-alcoholic steatohepatitis (NASH).


TSXV:TTI - Post by User

Post by MarketMakersson Nov 11, 2024 7:19pm
30 Views
Post# 36307440

TTI's Important Core Patent Allowed in Europe

TTI's Important Core Patent Allowed in Europe

Important Core Patent Allowed In Europe - Thiogenesis Therapeutics (TTI.v) Announced European Approval

 

Last week, Thiogenesis Therapeutics (TTI.v) announced the approval of its European patent for "Methods For The Treatment of Cysteamine Sensitive Disorders.".

 

This patent, set to expire in September 2037, complements previous patent approvals in the United States and Japan with the IP protection aligning with TTI's development of TTI-0102, a novel thiol-based prodrug designed to address mitochondrial diseases and related metabolic disorders by enhancing cellular antioxidant defenses.

 

TTI-0102 and Clinical Development

TTI-0102, TTI's lead compound, metabolizes into cysteamine, a precursor to glutathione and one of the body's primary antioxidants, and targets oxidative stress in the mitochondria, a factor in chronic diseases like MELAS, Leigh syndrome, and pediatric MASH.

 

Notably, TTI-0102’s unique sustained release allows for longer efficacy with fewer side effects and qualifies for the accelerated 505(b)(2) regulatory pathway in the U.S.

 

Further, TTI plans to initiate Phase 2 trials soon, aiming to provide significant clinical benefits for diseases with high oxidative stress.

 

Full News Release: https://www.newsfilecorp.com/release/228659

 

Posted on Behalf of Thiogenesis Therapeutics Corp.

 

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