RE:RE:RE:RE:RE:Big pharma is set to keep signing bigger deals in 2024Hotani et al. demonstrated that reovirus (pelareorep) reduces HIF-1α expression in hypoxic tumor fractions, contributing to the overall oncolytic effect by reducing transcription of HIF1α-responsive genes including VEGF and those responsible for maintaining cancer stem cell (CSC) phenotypes - consequently downregulating HIF-1α, glycolysis and lactic acid production - thus remodeling an immunosuppressive TME for the sequential addition of immune checkpoint inhibitors, for example.
Hotani T, Mizuguchi H, Sakurai F. Systemically administered reovirus-induced downregulation of hypoxia inducible factor-1α in subcutaneous tumors. Mol Ther Oncolytics 2019Hotani T, Mizuguchi H, Sakurai F. Systemically administered reovirus-induced downregulation of hypoxia inducible factor-1α in subcutaneous tumors. Mol Ther Oncolytics 2019
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