RE:RE:RE:JP Morgan healthcare conferenceBlockage of PI3K/Akt activation increases reovirus synthesis and viral yield, which results in enhnaced reovirus infection and the activation of an interferon (IFN)-stimulated response (a pro-inflammatory, cytokine activated response that results in the activation of the innate immune system) - thus turning "cold' tumors (like breast and pancreatic cancer) into 'hot' tumors.
Furthermore, ONCY's pelareorep is able to remodel a hostile tumor microenvironment (TME), which presents as a major obstacle to infilitrating T-lymphocytes by suppressing their function, into a TME with expanded T-cells that overcome T-cell dysfunction and T-cell exhaustion. Such a remodeled TME results in T-cells being trafficked towards the cancer cell surface, and by so doing, turning a cold tumor into a "hot" tumor, which then becomes ready for the sequential addition of an immune checkpoint inhibitor, as part of an immunochemotherapy combination of drugs for effective the treatment of various. cancers, like breast, pancreatic, anal and GI cancers.