COSCIENS Biopharma Inc T.AEZS

Safety/tolerability profile

[prophetoffactz]

It's been three weeks as of today since CZO reported its Q1 results and that all single dose levels of the avenanthramide pill to 960mg had been administered without a serious adverse event. These patients had to stay in a hospital for three days so there was no guarentee there wouldn't be serious issues. The Data Safety Monitoring Board was expected to make their decision soon concerning moving to the multi-dose portion of the clinical trial. Will we get a clean safety/tolerability profile? It would be an important step if we did given side-effects of competitors. Having a natural product with a clean safety/tolerability profile could be a competitive advantage.

Perplexity Ai: 
 

Avenanthramides, the polyphenolic compounds found in oats, have been shown to have potent antioxidant, anti-inflammatory, and anti-itch properties, with no significant side effects reported in the available research.Some key points about the safety and side effects of avenanthramides:

• Avenanthramides are bioavailable in humans and have been shown to have antioxidant activity after acute consumption of an enriched mixture.
• Topical application of 1-3 ppm avenanthramides mitigated inflammation in animal models without causing any adverse effects.
• 8 weeks of dietary avenanthramide supplementation effectively reduced exercise-induced muscle damage, inflammation, and pain in young men and women, with no reported side effects.
• The anti-inflammatory effects of avenanthramides are attributed to their ability to inhibit NF-κB activation and reduce pro-inflammatory cytokines, without causing toxicity.
• Avenanthramides have been used for centuries as a soothing agent to relieve itch and irritation associated with various skin conditions, again without any reported side effects.

In summary, the available evidence suggests that avenanthramides are safe and well-tolerated, with no significant side effects reported in the literature. Their potent antioxidant and anti-inflammatory properties make them a promising natural compound for various health applications.

[prophetoffactz]

We've never seen any preclinical data for the avenanthramide pill formulation or much of an explaination of what exactly it is. It is a mystery. Do they have preclinical data supporting a compelling potential efficacy profile that is further supported by other avenanthramide clinical trials; including in humans? A compelling data-driven argument for the pill in combination with human safety

[prophetoffactz]

CZO mentioned that it also combined avenanthramide with one of its newer PGX carriers with promising results. The current pill trial may be a building block to greater things as PGX also reaches the decision point for mass industrialization. A recent paper by another group combined yeast beta glucan with avenanthramide with interesting results. CZO has also been working with the Angiogenesis