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Editorial

 

touchREV Endocrinol

 

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. 2022 Nov;18(2):84-85.

 doi: 10.17925/EE.2022.18.2.84. Epub 2022 Sep 8.

Macimorelin Acetate for the Diagnosis of Childhood-onset Growth Hormone Deficiency

Rohan K Henry 1

Affiliations collapse

Affiliation

• 1Section of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine Columbus, OH, USA.

• PMID: 36694890
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• PMCID: PMC9835807
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• DOI: 10.17925/EE.2022.18.2.84

Abstract

Growth hormone provocation testing forms the cornerstone of the diagnosis of childhood growth hormone deficiency in clinical practice. Despite the widespread use of these tests, various criticisms have been levelled against them, such as the labour-intensive nature of the tests, their potential for serious adverse effects and their questionable reproducibility. Macimorelin acetate, a ghrelin mimetic approved for the diagnosis of adult growth hormone deficiency, could serve an unmet need in the diagnosis of childhood-onset growth hormone deficiency based on its good tolerability and benign side effect profile.

Keywords: Childhood-onset growth hormone deficiency; growth hormone; growth hormone deficiency; insulin tolerance test; macimorelin acetate; provocative test.

© Touch Medical Media 2022.

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Conflict of interest statement

Disclosures: Rohan K Henry has no financial or non-financial relationships or activities to declare in relation to this article.