COSCIENS Biopharma Inc T.CSCI

Metaformin, Avenanthramide, Anti-Aging

[prophetoffactz]

A study on metaformin was released on anti-aging. Avenanthramide has been studied too concerning anti-aging so I asked Perplexity Ai if they share any commonalities. The oldest living family in the world swears by two bowls of oats per day.

Perplexity Ai:

Avenanthramides (AVNs) and metformin exhibit some commonalities, particularly in their potential effects on aging and metabolic health, as highlighted in the context of recent research.

Common Mechanisms and Effects

1. Anti-Aging Properties: Both metformin and avenanthramides have been studied for their roles in decelerating aging processes. Metformin has been shown to influence the aging clock in male monkeys, suggesting its potential to extend lifespan and improve healthspan by modulating metabolic pathways and reducing inflammation. Similarly, avenanthramides, particularly avenanthramide C, have demonstrated antioxidant properties and the ability to reduce oxidative stress, which is a significant factor in aging and age-related diseases.
2. Inflammation and Oxidative Stress: Both compounds exhibit anti-inflammatory effects. Metformin reduces inflammation through various mechanisms, including the inhibition of pro-inflammatory cytokines and pathways like NF-κB. Avenanthramides also inhibit NF-κB activation and reduce the expression of inflammatory markers, thereby contributing to their anti-inflammatory effects. This shared action against inflammation may play a role in their respective benefits for metabolic health and aging.
3. Metabolic Regulation: Avenanthramides have been shown to inhibit glucose absorption in the intestine, which can contribute to improved glycemic control, similar to the effects of metformin, which enhances insulin sensitivity and reduces hepatic glucose production. This suggests that both substances may have complementary roles in managing blood sugar levels and supporting metabolic health.
4. Cellular Signaling Pathways: Both metformin and avenanthramides influence key signaling pathways associated with cellular health. Metformin activates AMPK, a crucial regulator of energy homeostasis, while avenanthramides have been linked to the modulation of the PI3K signaling pathway, which is involved in various cellular processes, including metabolism and inflammation.

Conclusion

In summary, metformin and avenanthramides share several commonalities, particularly in their anti-aging effects, anti-inflammatory properties, mechanisms of glucose regulation, and influence on critical cellular signaling pathways. These similarities suggest that both compounds may offer synergistic benefits in promoting metabolic health and mitigating age-related decline.

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Eric Topol

@EricTopol

 

The anti-aging impact of metformin (randomly assigned, with controls) in male monkeys after 40 months of treatment, a pan-omic clock assessment —~6 year regression of brain aging, with prevention of atrophy and enhanced cognitive ability —minimal effect on blood sugar —evidence for multi-organ decelerated aging https://cell.com/cell/abstract/S0092-8674(24)00914-0…

@CellCellPress

 

 

 

 

 

 

Eric Topol

@EricTopol

 

The anti-aging impact of metformin (randomly assigned, with controls) in male monkeys after 40 months of treatment, a pan-omic clock assessment —~6 year regression of brain aging, with prevention of atrophy and enhanced cognitive ability —minimal effect on blood sugar —evidence for multi-organ decelerated aging https://cell.com/cell/abstract/S0092-8674(24)00914-0…

@CellCellPress

[prophetoffactz]

Perplexity Ai: Synergistic Effects with Beta-Glucan Beta-glucans, such as those derived from yeast, are known for their immunomodulatory and health-promoting properties. When considering the impregnation of yeast beta-glucan with metformin, the synergistic effects could potentially enhance the health benefits associated with both compounds. The combination might leverage metformin's ability