Theralase Technologies Inc. V.TLT

450 Day CR rate

[Eoganacht]

Looking at the new swimmer's plot - there is 1 CR patient at 360 days awaiting their 450 day assessment. There are also 3 CR patients at 270 days and 4 CR patients at 180 days awaiting further assessment. All of these patients have had a CR since they were first tested. In 9 months, if they all maintain their CRs we will have a 40% CR rate at 450 days.

[DJDawg]

Based on the data to date, here is the probability for the perfect streak CR patients. Perfect CR from 90-360: 100% chance of staying CR at 450 Perfect CR from 90 to 270: 91% chance of staying CR till 450 Perfect CR from 90 to 180: 75% chance of staying CR till 450 So by my math: - the one CR at 360 stays CR - the 3 patients at 270 will likely convert to 3 CR's for the rest of the study

[Eoganacht]

Thanks. Taking this into account would mean a 36% 450 day CR rate in 9 months. At that point 53 patients will have been assessed at 450 days.  The final 47 patients should do better than the first 53 because there should be no undertreated patients. So maybe a 40% 450 day CR rate at the end of the trial?

[enriquesuave]

40-45% CR at 450 days could very well be reached if we also get a few IR patients to convert to CR.

[99942Apophis]

Am I wrong that yes CR is what we want for end of study trial but the FDA  also views IR + CR as important results as a third treatment could move a few patients into a solid CR classification? 

[Galaxym31]

The goal should be to extend life time without signifigant side effects .What is the extent of the cancer outside of CR .