Theralase Technologies Inc. V.TLT

It’s going to take a longggggg time I bet

[Dumbeldorfwhite]

To track down 25 people across two countries and convince them to come in for another exam, yikes. Why did the trial originally not plan for 18 month data is a question for the next AGM

[Legit62]

I dont believe that 18 month data has anything to do with us getting BTD or AA, dont know where that logic came from???

[Longholder99]

Soft but obvious bashers

[Dumbeldorfwhite]

From my understanding they do, they want ~25 patients worth of data extending out to 18 months....could be clarified 

[DJDawg]

I'm confused as to what you are describing. There is no tracking and convincing. 14 patients were CR at 15 months. Cancer patients don't say goodbye to their uro-oncologist at 15 m. There is routine follow up for years. Most importantly, you don't need anything more than to ask about the follow up cytologies. If the urine remains free of any cancer cells shedding AND they add a

[N0taP00p]

@DJDawg, there's an additional step besides getting this data from the local PIs, isn't there?   After each center provides the data, they have to now validate it through a central lab. All this , when they're struggling to raise money.  If history repeats , we will be left with more questions than answers after the quarterly.   

[N0taP00p]

And that's why I had mentioned Q1 "24 before as the earliest estimate for BTD.   Collection of data, validation of data, compile and submit for pre-BTD, wait for approval,  then compile and submit for BTD, wait for approval. All this, with limited money and the holidays in between.  

[Oilminerdeluxe]

Most things take longer than expected with TLT. One just have to accept it.

[Pandora]

I'll display my ignorance here. What is an aptimer relative to a vaccine? Are they completey separate paths of research? McMaster University working with a small company on an aptimer seems to have reached a significant level. Zentek is now looking for a partner to continue further. November 29, 2023 Zentek Ltd. (“Zentek” or the “Company”) (Nasdaq: ZTEK; TSX-V: ZEN), an intellectual

[Eoganacht]

Hi Pandora - Google says: What is an Aptamer? The term “Aptamer” was coined by Andy Ellington. It stems from the Latin terms “aptus,” meaning to fit, and “meros,” meaning part. Aptamers are short, single-stranded DNA or RNA (ssDNA or ssRNA) molecules that can selectively bind to a specific target, including proteins, peptides, carbohydrates, small molecules, toxins, and

[Pandora]

Thanks Eoganacht, I had looked at the Google definition but it does not answer my thinking. i.e. does this aptimer have any place in the development of a vaccine? Just wondering if the TLT vaccine group in Manitoba would get any use or benefit out of it. Clutching at straws I guess.

[DJDawg]

Validating through a central lab is a complicated way of saying the following - pick one pathologist who is a bladder specialist (vs a generalist pathologist) - hire him - pull the 14 patient stored cytology and biopsy samples and mail them to the central pathologist to review and confirm as CR - most pathologists can review about 50-100 samples a day depending on tissue so quick on that part

[Dumbeldorfwhite]

A few months for a company that barely has any cash