Theralase Technologies Inc. V.TLT

PSSST

[parahyangam]

Anybody remember QLT?

Chlorophyllin tagged with photophrin?

Very promising. Good underlying biological model.

Made it all the way to phase III cancer trials

BUT

complete ablation of all tumour cells could not be achieved.

Partial salvation was with Visudyne.

Visudyne had a good ride but now largely bypassed by more eficacious treatments for macular degeneration.   

Lots of invested capital went down the drain.

Caveat emptor.

[CancerSlayer]

Can you please cite the study where Chlorophyllin was promisingy used against BCG-unresponsive NMIBC?   Chlorophyllin to TLD 1433 is an apple to an orange... Your comments are irrelevant.

[Legit62]

Completely agree CancerSlayer, not even relevant

[DJDawg]

Is this what you mean? Genuinely curious. Photofrin Photofrin® (Porfimer Sodium, QLT Phototherapeutics, Inc., Vancouver, BC, Canada), a second-generation photosensitizer, was purified from the HpD using size exclusion chromatography to remove low-molecular-weight compounds (47). Photofrin was first approved for bladder cancer in Canada in 1993 and then approved for early-stage lung

[CancerSlayer]

He's trying to stir the pot... As far as I'm aware, two key players come to the forefront with regards to the photosensitizer realm over the past 30+ years.  These include Photofrin & TLD 1433.  The former had a promising early response rate (highlighting the potential for PDT), but had two major disadvantages in the form of high-intensity/sunlight-mediated skin toxicity

[Eoganacht]

Right! One other key player is ALA which is used as a PS in PDT for actinic keratosis. It is also used in fluorescence-guided gbm tumour resection as it causes cancer cells to glow, allowing the surgeon a more visible target when resecting. It is also the only photosensitizer other than Ruvidar/Rutherrin that can cross the bloodbrain barrier. It was used by Dr. Munegowda as a direct comparator

[CancerSlayer]

Thanks for noting that Eoganacht.... I was primarily focusing on photosensitizer use against bladder cancer.  In this instance, while ALA-PDT demonstrated a promising response rate & was selective for cancer cells, it suffered from poor penetration when applied topically & demonstrated significant toxicity when given intravenously (referencing the 9/2022 article, "Photodynamic

[Eoganacht]

Yes. 5-ALA does not seem to be a good option for NMIBC PDT. 5-ALA is more useful in photodynamic diagnosis-assisted transurethral resection of bladder tumours - PDD-TURBT - much as it is used to aid gbm resection. https://pubmed.ncbi.nlm.nih.gov/38695571/

[CancerSlayer]

Yep...as for GBM, there is limited competition, but it seems our biggest will be a compound named Ogremorphin (OGM), which is being studied at Michigan State Univ, & the HTX-GBM-01 clinical trial (a Ph1/2 intraoperative PDT trial).  Our tech of course has the advantage of having both bioavailability & treatment versatility...can be used intraoperatively/intravenously & activated

[CancerSlayer]

Winner is TLD 1433...or more precisely, Rutherrin-PDT.

[Kayz88]

My brother in Christ. My money is already down the drain, do you think this hurts me? After years of being in this company, I'm anti-fragile, unshakeable and just filled with a bit of hope that the science will work.