MethylGene to Present Mocetinostat Data at the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting

MONTREAL, CANADA--(Marketwired - May 28, 2013) - MethylGene Inc. (TSX:MYG) today announced that clinical data for mocetinostat, the spectrum selective histone deacetylase (HDAC) inhibitor, will be presented at the 2013 ASCO Annual Meeting to be held in Chicago, Illinois from May 31^st to June 4, 2013.

Data will be presented from two phase II clinical programs describing the safety and efficacy of mocetinostat as monotherapy in diffuse large cell B-cell and follicular lymphomas and in combination with 5-azacitidine in myelodysplastic syndrome.

Poster Presentation: A phase II study of mocetinostat, an oral isotype-specific histone deacetylase (HDAC) inhibitor, in combination with 5-azacitidine in patients with myelodysplastic syndrome (MDS).

Poster Discussion Session: A phase II study of single agent mocetinostat, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in patients with diffuse large B-cell (DLBCL) and follicular (FL) lymphomas.

About Mocetinostat

Mocetinostat is an orally available, isoform selective histone deacetylase, or HDAC, inhibitor that has been evaluated over 400 patients in multiple Phase I and Phase II clinical trials for the treatment of hematological malignancies and solid tumors. Based on the promising early phase single agent responses in patients with Hodgkin's disease we are evaluating Phase II study designs in these patients. In addition, we are evaluating plans for development of this agent in combination with azacitidine for the treatment of patients with intermediate and high risk myelodysplastic syndromes, or MDS. Prognosis for the intermediate and high-risk category of MDS patients is poor and there is a need for treatments that will improve clinical outcomes. Mocetinostat is partnered with Taiho Pharmaceutical for selected Asian Territories.

About MethylGene

MethylGene is a publicly-traded biopharmaceutical company engaged in the development and commercialization of novel therapeutics for the treatment of cancer. Our compounds result from internal chemistry efforts targeting the active sites of enzymes that are key drivers of tumor growth. Our clinical development programs are focussed on treating selected tumor types that express high levels of these targets in order to most effectively address unmet patient needs. Our lead program in clinical development is MGCD265, a multi-targeted small molecule kinase inhibitor for treatment of oncology patients with solid tumors. We are also evaluating development opportunities in oncology for mocetinostat, a spectrum-selective HDAC inhibitor and MGCD516, a kinase inhibitor with a distinct target profile.

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Forward-Looking Statements

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However, whether actual results and developments will conform with our expectations and predictions is subject to a number of risks, assumptions and uncertainties, many of which are beyond our control, and the effects of which can be difficult to predict. In evaluating any forward-looking statements in this news release, MethylGene cautions readers not to place undue reliance on any forward-looking statements. Readers should specifically consider the various factors which could cause actual events or results to differ materially from those indicated by our forward-looking statements. Unless otherwise required by applicable securities laws, MethylGene does not intend, nor does it undertake any obligation, to update or revise any forward-looking statements contained in this news release to reflect subsequent information, events, results or circumstances or otherwise.