Ocular Therapeutix, Inc. (NASDAQ:OCUL), a biopharmaceutical company
focused on the development and commercialization of innovative therapies
for diseases and conditions of the eye, announced new data will be
presented on the company’s sustained release technology at the upcoming
Association for Research in Vision and Ophthalmology (ARVO) Annual
Meeting at the Colorado Convention Center in Denver, Colorado, from May
3-7, 2015.
The data presented will focus on the company’s proprietary hydrogel
injectable depot technology using bevacizumab and other anti-VEGF agents
as model proteins to demonstrate viability of the platform as a means of
developing sustained release therapies for retinal diseases. The poster
presentations take place on Monday, May 4th,
during the 8:30-10:15 a.m. MDT VEGF Therapy session.
-
Preservation of Bevacizumab Anti-VEGF Bioactivity and Monomeric
Structure During Processing into a Sustained Release Bevacizumab
Intravitreal Depot
(Poster B0226) – Compatibility of
protein-based drugs with the hydrogel technology.
-
Pharmacokinetics of Bevacizumab Sustained Release from Intravitreal
Hydrogel Depots in a Rabbit Model Compared to a single Avastin Dose
(Poster
B0248) - Comparison of drug concentration in vitro and in
intraocular tissues when released from the hydrogel depots containing
various commercially available anti-VEGF agents compared to a
conventional bolus injection of an anti-VEGF agent.
-
Tolerability of Intravitreal Hydrogel Depots for Anti-VEGF
Sustained Release in a Rabbit Model (Poster B0222) – Biocompatible
nature of the hydrogel depot when placed in an intravitreal
environment.
Ocular Therapeutix is developing hydrogel-based drug delivery depots
designed to release anti-VEGF compounds over a sustained period
following administration by intravitreal injection. The goal for this
program is to provide drug release over a four to six month period,
thereby reducing the frequency of current monthly or bi-monthly
injections.
“We have been able to demonstrate that an anti-VEGF maintains its
structure and bioactivity within our hydrogel. We have further shown
tolerability and drug release of clinically meaningful concentration and
duration. This technology provides the possibility of a new
biocompatible, bioresorbable intravitreal hydrogel depot platform. We
look forward to advancing the development of this program,” said Peter
Jarrett, Ph.D., Chief Scientific Officer at Ocular Therapeutix.
In addition, Ocular Therapeutix will be presenting several additional
posters based on the Company’s anterior segment therapies, including:
Sunday, May 3, 2015
-
Influence of Storage Temperature on Sustained Release Dexamethasone
Pharmacokinetics in a Beagle Model
(Poster C0092) Session:
Physiology, pharmacology, inflammation and neuroprotection. 8:30-10:15
a.m. MDT
-
Dose-Based Pharmacokinetics of Sustained Release Dexamethasone in
Beagles.
(Poster C0093) Session: Physiology,
pharmacology, inflammation and neuroprotection. 8:30-10:15 a.m. MDT
Monday, May 4, 2015
-
A Toxicological Evaluation of a Single Dose, 90 Day Sustained
Release Travoprost Punctum Plug in Canines (Poster D0236) Session:
Biochemistry, physiology and pharmacology of glaucoma and aqueous
humor dynamics. 11:00AM-12:45 p.m. MDT
Wednesday, May 6, 2015
-
Evaluating Sustained Release Dexamethasone for the Treatment of
Chronic Allergic Conjunctivitis Using a Modified Conjunctival Allergen
Challenge (Ora-CAC®) Model (Poster A0143)
Session: Corneal inflammation due to allergy, dry eye, or transplant.
3:45-5:30 p.m. MDT
Thursday, May 7, 2015
-
One-Year Stability of a Sustained Release Travoprost Biodegradable
Hydrogel Punctum Plug for the Treatment of Glaucoma (Poster C0137)
Session: Drug studies and pharmacology. 8:30-10:15 a.m.
MDT
About Ocular Therapeutix, Inc.
Ocular Therapeutix, Inc. (NASDAQ: OCUL) is a biopharmaceutical company
focused on the development and commercialization of innovative therapies
for diseases and conditions of the eye using its proprietary hydrogel
platform technology. Ocular Therapeutix's lead product candidates are in
Phase 3 clinical development for post-surgical ocular inflammation and
pain, and Phase 2 clinical development for glaucoma, allergic
conjunctivitis, and dry eye disease. The Company is also evaluating
sustained-release injectable anti-VEGF drug depots for back-of-the-eye
diseases. Ocular Therapeutix's first product, ReSure®
Sealant, is FDA-approved to seal corneal incisions following cataract
surgery.
Forward Looking Statements
Any statements in this press release about future expectations, plans
and prospects for the Company, including statements about the
development of the Company’s product candidates, such as the ongoing
development of the Company’s hydrogel injectable depot technology,
the advancement of the Company's other product candidates and other
statements containing the words "anticipate," "believe," "estimate,"
"expect," "intend", "goal," "may", "might," "plan," "predict,"
"project," "target," "potential," "will," "would," "could," "should,"
"continue," and similar expressions, constitute forward-looking
statements within the meaning of The Private Securities Litigation
Reform Act of 1995. Actual results may differ materially from those
indicated by such forward-looking statements as a result of various
important factors. Such forward-looking statements involve substantial
risks and uncertainties that could cause the Company’s clinical
development programs, future results, performance or achievements to
differ significantly from those expressed or implied by the
forward-looking statements. Such risks and uncertainties include, among
others, those related to the timing and costs involved in
commercializing ReSure® Sealant, the initiation
and conduct of clinical trials, availability of data from clinical
trials and expectations for regulatory approvals, the Company’s
scientific approach and general development progress, the availability
or commercial potential of the Company’s product candidates, the
sufficiency of cash resources and need for additional financing or other
actions and other factors discussed in the “Risk Factors” section
contained in the Company’s Annual Report on Form 10-K for the year ended
December 31, 2014 on file with the Securities and Exchange Commission.
In addition, the forward-looking statements included in this press
release represent the Company’s views as of the date of this release.
The Company anticipates that subsequent events and developments will
cause the Company’s views to change. However, while the Company may
elect to update these forward-looking statements at some point in the
future, the Company specifically disclaims any obligation to do so.
These forward-looking statements should not be relied upon as
representing the Company’s views as of any date subsequent to the date
of this release.
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