NEWARK, Calif., June 13, 2016 (GLOBE NEWSWIRE) -- Revance Therapeutics, Inc. (NASDAQ:RVNC), a biotechnology company
developing botulinum toxin products for use in aesthetic and therapeutic indications, today reported results from its REALISE 1
Phase 3 trial of DaxibotulinumtoxinA Topical Gel (RT001) to treat patients with moderate to severe lateral canthal lines, or crow’s
feet.
In REALISE 1, DaxibotulinumtoxinA Topical Gel (RT001) did not achieve its co-primary and other endpoints. The
co-primary efficacy endpoints in the trial were composite measurements of 2-point or greater and 1-point or greater improvement in
lateral canthal lines between baseline and 28 days after treatment, as graded by the Investigator’s Global Assessment of Lateral
Canthal Lines (IGA-LCL) and the Patient Severity Assessment (PSA). RT001 topical generally appeared to be well-tolerated in this
study.
“We are disappointed with the results of the REALISE 1 trial. The data was unambiguous, and we do not plan to
continue development of RT001 topical for crow’s feet. Based on these results, we have also decided not to pursue the current
clinical development plan for RT001 in axillary hyperhidrosis. We are grateful to all the patients and investigators for
their participation in the REALISE 1 trial,” said Dan Browne, President and Chief Executive Officer at Revance. “Given the positive
results in our recent Phase 2 BELMONT active comparator trial, we will focus our future development efforts and financial resources
on DaxibotulinumtoxinA for Injection (RT002).”
Mr. Browne continued, “Looking ahead to the second half of this year, we remain on track to initiate RT002
injectable Phase 3 clinical trials for glabellar lines and report interim Phase 2 results in cervical dystonia. We recently held an
End-of-Phase 2 meeting with the U.S. Food and Drug Administration (FDA) regarding our RT002 injectable program for glabellar lines.
We believe the meeting was informative and productive. Meeting minutes are in process, and consistent with company and industry
practice, we look forward to providing further updates when we have final minutes from the FDA.”
At the end of March 2016, Revance had cash and investments of $236.6 million. Based on its current development
plans, the company now expect its cash and investments to fund its operations into the second quarter of 2018.
Phase 3 Trial Design – REALISE 1
The Phase 3 trial was a randomized, double-blind, parallel-group, placebo-controlled study to evaluate the safety and efficacy of
DaxibotulinumtoxinA Topical Gel (RT001) for the treatment of moderate to severe lateral canthal lines. A total of 450 adult
patients were enrolled at seven sites in the United States and were randomized 1:1 to a single treatment of either RT001 or placebo
topical gel applied to lateral canthal lines on both sides of the face using Revance’s proprietary applicator.
DaxibotulinumtoxinA for Injection (RT002) Pipeline Programs
Planned Phase 3 Program for the Treatment of Glabellar (Frown) Lines - In the BELMONT Phase 2 Active Comparator
Study for the treatment of glabellar lines, Revance’s RT002 injectable achieved 6-month median duration of effect for the 40-unit
dose, showed a statistically significantly greater duration than the study comparator, BOTOX® Cosmetic, and appeared to
be safe and well-tolerated. The company plans to initiate a Phase 3 program in the second half of 2016.
Phase 2 Trial for the Treatment of Cervical Dystonia - Revance’s Phase 2 dose-escalating study of
RT002 injectable for the treatment of cervical dystonia is enrolling patients into Cohort 2, following the encouraging, preliminary
results from a planned six-week safety review for patients enrolled in Cohort 1 (n=12) of the study. Revance expects to share
interim results from this study in the second half of 2016.
Conference Call
Revance management will host a conference call and webcast today, June 13, at 1:30 pm PDT/ 4:30 pm EDT. Individuals interested in
listening to the conference call may do so by dialing (855) 453-3827 for domestic callers, or (484) 756-4301 for international
callers and reference conference ID: 32469026; or from the webcast link in the investor relations section of the company's website
at: www.revance.com.
A replay of the call will be available beginning June 13, 2016 at 4:30 pm PDT/ 7:30 pm EDT through midnight on June
14, 2016. To access the replay, dial (855) 859-2056 or (404) 537-3406 and reference conference ID: 32469026. The webcast will be
available in the investor relations section on the company's website for 30 days following the completion of the call.
About Revance Therapeutics, Inc.
Revance, a Silicon Valley-based biotechnology company, is committed to the advancement of remarkable science. The company is
developing a portfolio of products for aesthetic medicine and underserved therapeutic specialties, including dermatology and
neurology. Revance’s trajectory to commercial success begins with the company’s novel and proprietary TransMTS®
carrier-peptide delivery system applied to botulinum toxin.
Revance is developing daxibotulinumtoxinA, the company’s highly purified botulinum toxin, for a broad spectrum of
aesthetic and therapeutic indications, including facial wrinkles and muscle movement disorders.
The company holds worldwide rights for all indications of DaxibotulinumtoxinA Topical Gel (RT001),
DaxibotulinumtoxinA for Injection (RT002) and the TransMTS technology platform. Beyond botulinum toxin, Revance believes the
TransMTS technology can be applied to transdermal, mid-dermal, or deep tissue delivery of a variety of other macromolecules.
More information on Revance can be found at www.revance.com.
"Revance Therapeutics", TransMTS®, “Remarkable Science Changes Everything”, and the Revance logo are
registered trademarks of Revance Therapeutics, Inc.
BOTOX® is a registered trademark of Allergan, Inc.
Forward Looking Statements
This press release contains forward-looking statements, including, but not limited to: statements about our business strategy,
our investigational drug product candidates, expected efficacy of our drug product candidates, clinical development, timeline and
other goals and market for our anticipated products, plans and prospects and statements about potential benefits of our drug
product candidates and our technologies.
Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ
materially from our expectations. These risks and uncertainties include, but are not limited to: the outcome, cost, and timing of
our product development activities and clinical trials; the uncertain clinical development process, including the risk that
clinical trials may not have an effective design or generate positive results; our ability to obtain and maintain regulatory
approval of our drug product candidates; our ability to obtain funding for our operations; our plans to research, develop, and
commercialize our drug product candidates; our ability to achieve market acceptance of our drug product candidates; unanticipated
costs or delays in research, development, and commercialization efforts; the applicability of clinical study results to actual
outcomes; the size and growth potential of the markets for our drug product candidates; our ability to successfully commercialize
our drug product candidates and the timing of commercialization activities; the rate and degree of market acceptance of our drug
product candidates; our ability to develop sales and marketing capabilities; the accuracy of our estimates regarding expenses,
future revenues, capital requirements and needs for financing; our ability to continue obtaining and maintaining intellectual
property protection for our drug product candidates; and other risks. Detailed information regarding factors that may cause actual
results to differ materially from the results expressed or implied by statements in this press release may be found in Revance's
periodic filings with the Securities and Exchange Commission (the "SEC"), including factors described in the section
entitled "Risk Factors" of our quarterly report on Form 10-Q filed on May 10, 2016. These forward-looking statements speak only as
of the date hereof. Revance disclaims any obligation to update these forward-looking statements.
Contacts Investors: Revance Therapeutics Jeanie Herbert (714) 325-3584 jherbert@revance.com Burns McClellan Ami Bavishi (212) 213-0006 abavishi@burnsmc.com Trade Media: Nadine Tosk (504) 453-8344 nadinepr@gmail.com
